{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:32:41Z","timestamp":1745469161192,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells Tissues Organs"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Several preclinical studies have shown that &lt;i&gt;Escherichia coli-&lt;\/i&gt;derived bone morphogenetic protein-2 (E-BMP-2) is as effective as mammalian cell-derived bone morphogenetic protein-2 (C-BMP-2) in the treatment of bone defects. However, further investigation of the effectiveness and determination of the optimal dosage of E-BMP-2 in large animals are still necessary before its full application in humans. This study investigated the efficiency of different concentrations of E-BMP-2 adsorbed in \u03b2-TCP for bone augmentation and osseointegration of immediate dental implants in a swine socket lift model. Following exposure of the maxillary sinus lateral wall, a 3.4-mm (diameter) cavity was drilled and filled with 0.1 g of \u03b2-TCP containing different doses of E-BMP-2 (0, 10, 30, or 100 \u03bcg\/site) to lift the Schneiderian membrane. A dental implant was then immediately inserted. Bone-to-implant contact (BIC) and bone density (BD) examined via histological analysis were used as parameters to assess E-BMP-2 efficiency in bone formation. The implant stability quotient (ISQ) was measured using Osstell to determine the effect of E-BMP-2\/\u03b2-TCP on implant stability. After 8 weeks, the groups that received 30 and 100 \u03bcg of E-BMP-2 showed substantial new bone formation in the elevated space, while no bone formation was observed with \u03b2-TCP alone. Accordingly, BIC and BD presented a dose-dependent response to increasing doses of E-BMP-2. However, there was no increase in implant stability with E-BMP-2 treatment. In conclusion, the E-BMP-2\/\u03b2-TCP combination was efficient in bone formation and osseointegration of dental implants in a socket lift model in mini-pigs.<\/jats:p>","DOI":"10.1159\/000369061","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T07:57:19Z","timestamp":1421913439000},"page":"249-255","source":"Crossref","is-referenced-by-count":10,"title":["Efficient Bone Formation in a Swine Socket Lift Model Using &lt;b&gt;&lt;i&gt;Escherichia coli-&lt;\/i&gt;&lt;\/b&gt;Derived Recombinant Human Bone Morphogenetic Protein-2 Adsorbed in \u03b2-Tricalcium Phosphate"],"prefix":"10.1159","volume":"199","author":[{"given":"Mitsuaki","family":"Ono","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Sonoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katushi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaka","family":"Oida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehiko","family":"Shinkawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryu","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai T.","family":"Pham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio S.","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuo","family":"Kuboki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,1,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02222.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.89B5.19039"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2010.02.010"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01909.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2012.04.005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.09.063"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.4.5.741"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(05)80621-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2751"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20120725-04"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000356947"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12114"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.08.028"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2012.12.041"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30715"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-009-0040-3"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEA.2010.0490"}],"container-title":["Cells Tissues Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/369061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/369061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:58:10Z","timestamp":1745431090000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000369061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,2,1]]},"published-print":{"date-parts":[[2015,2,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000369061","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5127268","asserted-by":"subject"}]},"ISSN":["1422-6405","1422-6421"],"issn-type":[{"type":"print","value":"1422-6405"},{"type":"electronic","value":"1422-6421"}],"subject":[],"published":{"date-parts":[[2014]]}}}