{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:59:39Z","timestamp":1778615979931,"version":"3.51.4"},"reference-count":118,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfus Med Hemother"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>The search for genetic determinants of alloimmunization in sickle cell disease transfusion recipients was based on two premises: i) that polymorphisms responsible for stronger immune and\/or inflammatory responses and hemoglobin \u03b2&lt;sup&gt;S&lt;\/sup&gt; mutation were co-selected by malaria; and ii) that stronger responder status contributes to development of lupus. We found a marker of alloimmunization in the gene encoding for Ro52 protein, also known as Sj\u00f6gren syndrome antigen 1 (SSA1) and TRIM21. Surprisingly, the nature of the association was opposite of that with lupus; the same variant of a polymorphism (rs660) that was associated with lupus incidence was also associated with induction of tolerance to red blood cell antigens during early childhood. The dual function of Ro52 can explain this apparent contradiction. We propose that other lupus\/autoimmunity susceptibility loci may reveal roles of additional molecules in various aspects of alloimmunization induced by transfusion as well as during pregnancy.<\/jats:p>","DOI":"10.1159\/000369145","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T14:24:05Z","timestamp":1418048645000},"page":"436-445","source":"Crossref","is-referenced-by-count":14,"title":["Genetics of Transfusion Recipient Alloimmunization: Can Clues from Susceptibility to Autoimmunity Pave the Way?"],"prefix":"10.1159","volume":"41","author":[{"given":"Zohreh","family":"Tatari-Calderone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi L.C.","family":"Luban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislav","family":"Vukmanovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70204-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37497265338.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21550"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-327361"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22327"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830050204"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199006073222301"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00007.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1990.30891020325.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1992.32993110751.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05425.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1995.35195090655.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/00129804-200311000-00006"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02435.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2012.07.014"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2012.06.006"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02819.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-146415"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00946.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328313695e"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01801.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.03.008"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2760"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb08318.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1998.tb01060.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000041049"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306070005"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306070007"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306072311"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.11.030"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2004.03563.x"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0339"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1097\/01.ANC.0000338019.56405.29"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00233.x"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.02.081"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199711150-00008"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199102000-00013"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005030293"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60912-X"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.01051.x"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200103150-00021"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-007-0358-4"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh325"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1159\/000073201"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(99)00039-7"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00293-6"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2003.00116.x"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2428"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.21439"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000491"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4857.290"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906198106"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1038\/ng0694-169"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197608052950602"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1086\/432519"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20304"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114968"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0832411100"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1664"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.12.027"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21846"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205027"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1038\/172603a0"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1126\/science.102.2651.400"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02799.x"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1038\/nri1394"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1038\/ni0311-189"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1038\/nri2508"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1086\/314571"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.6.3200"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-009-8122-5"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1986.26386209381.x"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1990.tb02055.x"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00028-7"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1824"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3528(96)90002-0"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/58.1.89"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.11.1839"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601040103"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-100010"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.9.1385"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003572"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-01-069245"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)00098-X"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/628963"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(80)90252-1"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2006.00491.x"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015041"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000163397.53466.0F"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2003.024"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1086\/509892"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2012.08.006"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.12.017"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.2731"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1002\/9780470986868.ch5"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1002\/9780470986868.ch6"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.10.6277"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.01.014"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.3.1780"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090585"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2548"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-014-0017-4"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-996-0063-x"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.9979"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31817c4cb8"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1159\/000170814"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1038\/nri1702"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.3109\/10611861003649746"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-1-39"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.10.49"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.10.004"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2.4.228"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-985069"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1586\/egh.09.61"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1159\/000107708"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1006\/smim.2000.0320"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2011.01038.x"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.05.025"}],"container-title":["Transfusion Medicine and Hemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/369145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/369145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:58:45Z","timestamp":1745431125000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000369145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":118,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000369145","archive":["Portico"],"relation":{},"ISSN":["1660-3796","1660-3818"],"issn-type":[{"value":"1660-3796","type":"print"},{"value":"1660-3818","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}