{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T16:23:32Z","timestamp":1774715012223,"version":"3.50.1"},"reference-count":18,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Infantile hemangiomas (IHs) are common childhood tumors. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; Our study aimed to compare the efficacy and side effects of imiquimod and timolol maleate for the treatment of proliferating superficial IHs. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A total of 54 patients with superficial IHs were enrolled in this study. Each lesion was evenly divided into two parts. One part was treated with 5% imiquimod cream once every other day, and the other part was smeared with 0.5% timolol maleate eye drops thrice daily. After 16 weeks of treatment, the thickness, color and size of each lesion were measured, and the side effects were recorded. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The efficacy rates for imiquimod and timolol maleate were 81.4 and 88.9%, respectively, but the difference between treatments was not significant. However, timolol maleate showed better effects for color involution, onset time and side effects than imiquimod. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Timolol maleate might be the first choice for the topical treatment of superficial IHs.<\/jats:p>","DOI":"10.1159\/000369164","type":"journal-article","created":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T08:00:30Z","timestamp":1422259230000},"page":"150-155","source":"Crossref","is-referenced-by-count":21,"title":["Open-Label Nonrandomized Left-Right Comparison of Imiquimod 5% Ointment and Timolol Maleate 0.5% Eye Drops in the Treatment of Proliferating Superficial Infantile Hemangioma"],"prefix":"10.1159","volume":"230","author":[{"given":"Li","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui Zhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Xi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,1,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(83)80043-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.200"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.370"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.7.881"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0708819"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181c2a55a"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.04.022"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.06.011"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01520.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000334778"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12150"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.126586"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2174\/092986707780059625"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.09.008"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12192"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00857.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1159"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.08.014"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/369164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/369164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:59:06Z","timestamp":1745431146000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000369164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,1]]},"published-print":{"date-parts":[[2015,2,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000369164","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}