{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:31:47Z","timestamp":1776918707753,"version":"3.51.2"},"reference-count":33,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background\/Aims:<\/i><\/b> We investigated the effects of tyrosine kinase inhibitors (TKIs) on the expression of apoptosis-related genes (BCL-2 and death receptor family members) in chronic myeloid leukemia (CML) patients. <b><i>Methods:<\/i><\/b> Peripheral blood mononuclear cells from 32 healthy subjects and 26 CML patients were evaluated before and after treatment with imatinib mesylate (IM) and dasatinib (DAS) by quantitative PCR. <b><i>Results:<\/i><\/b> Anti-apoptotic genes <i>(c-FLIP <\/i>and<i> MCL-1)<\/i> were overexpressed and the pro-apoptotic <i>BIK <\/i>was reduced in CML patients. Expression of <i>BMF, A1, c-FLIP, MCL-1, CIAP-2 <\/i>and <i>CIAP-1 <\/i>was modulated by DAS. In IM-resistant patients, expression of <i>A1, c-FLIP, CIAP-1<\/i> and <i>MCL-1 <\/i>was upregulated, and <i>BCL-2<\/i>,<i> CIAP-2<\/i>,<i> BAK, BAX, BIK <\/i>and <i>FASL <\/i>expression was downregulated. <b><i>Conclusion:<\/i><\/b> Taken together, our results point out that, in CML, DAS interferes with the apoptotic machinery regulation. In addition, the data suggest that apoptosis-related gene expression profiles are associated with primary resistance to IM.<\/jats:p>","DOI":"10.1159\/000369446","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T12:20:09Z","timestamp":1424175609000},"page":"354-364","source":"Crossref","is-referenced-by-count":15,"title":["Apoptosis-Related Gene Expression Profile in Chronic Myeloid Leukemia Patients after Imatinib Mesylate and Dasatinib Therapy"],"prefix":"10.1159","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6874-184X","authenticated-orcid":false,"given":"Aline Fernanda","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gislane L.V.","family":"de 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