{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:41:25Z","timestamp":1789706485245,"version":"4.0.1"},"reference-count":18,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Congenital nasal pyriform aperture stenosis (CNPAS) is an increasingly recognised cause of upper airway obstruction associated with midline abnormalities. Studies have described pituitary dysfunction in 40% of patients. We aimed to develop guidelines for: (a) the early identification of pituitary insufficiency to minimise surgical risk and (b) to stratify patients for follow-up. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Retrospective case note review of patients with CNPAS between 2000 and 2014 in a tertiary paediatric unit. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; 20 patients (12 female:8 male) were analysed; 16 were diagnosed during the neonatal period while 4 were diagnosed later. There was no consistent approach in the evaluation of the pituitary axis at diagnosis. Pituitary dysfunction was identified in 3 (15%) patients, 2 of whom were found during evaluation of short stature in mid-late childhood. Hypoglycaemia and conjugated hyperbilirubinaemia, but not the degree of stenosis, were highly predictive of pituitary dysfunction (p &lt; 0.05). Available height standard deviation score (SDS) data at 1 year of 70% of our patients identified both of the late-diagnosed growth hormone-deficient patients, with SDS of -2.6 and -3.6, respectively. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; All CNPAS patients should have MRI of the brain and baseline endocrine investigations at diagnosis. Growth monitoring for at least 1 year is recommended as low, or falling, height SDS at 1 year is a good predictor of pituitary dysfunction.<\/jats:p>","DOI":"10.1159\/000369805","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T07:36:30Z","timestamp":1426491390000},"page":"302-310","source":"Crossref","is-referenced-by-count":12,"title":["Early Identification of Pituitary Dysfunction in Congenital Nasal Pyriform Aperture Stenosis: Recommendations Based on Experience in a Single Centre"],"prefix":"10.1159","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2866-6360","authenticated-orcid":false,"given":"Suet Ching","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"McDevitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Andrew","family":"Clement","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Wynne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avril","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm D.C.","family":"Donaldson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0689-5549","authenticated-orcid":false,"given":"S. Faisal","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Guftar","family":"Shaikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198901000-00016"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1992.01880090105027"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(94)90012-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000238380.03683.cb"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050763"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(94)01096-G"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70343-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s004310051026"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.213.2.r99oc38495"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980228)17:4<407::AID-SIM742>3.0.CO;2-L"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000113"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20010722)102:1<1::AID-AJMG1336>3.0.CO;2-U"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.17.8102"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03572.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000350829"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2004.07.011"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.107187"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.otorri.2009.11.001"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/369805","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/369805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:05:51Z","timestamp":1745431551000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000369805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":18,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,6,1]]},"published-print":{"date-parts":[[2015,6,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000369805","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}