{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:52:25Z","timestamp":1788357145232,"version":"build-2803163510"},"reference-count":22,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; It would be advantageous for the treatment of neonatal respiratory distress syndrome if effective amounts of surfactant could be delivered by nebulization. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To investigate lung deposition and distribution of nebulized porcine surfactant using an investigational eFlow\u00ae neonatal nebulizer. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; While lying on one side, 1-day-old piglets inhaled 200 mg\u00b7kg&lt;sup&gt;-1&lt;\/sup&gt; of nebulized surfactant via mask, nasal prongs, or tracheal tube. The surfactant was diluted with normal saline to 40 mg\u00b7ml&lt;sup&gt;-1&lt;\/sup&gt; and labeled with &lt;sup&gt;99m&lt;\/sup&gt;technetium-labelled nanocolloid. Undiluted surfactant (80 mg\u00b7ml&lt;sup&gt;-1&lt;\/sup&gt;) was instilled tracheally in a fourth group. Each group had 8 animals. Lung deposition was measured by gamma scintigraphy, and deposition values were presented as a percentage of the nebulized or instilled dose. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The median lung deposition of inhaled surfactant was 5% (range 3-16) via mask, 14% (2-40) via prongs, and 45% (25-56) via tracheal tube (p &lt; 0.05). It was 88% (71-96) with instillation. In all groups, the surfactant preferentially went to the dependent lung. Deposition ratios (upper lung\/both lungs) were 0.32 (0.13-0.58), 0.15 (0.05-0.58), 0.16 (0.11-0.23), and 0.08 (0.03-0.46). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Using this nebulizer, the lung depositions of porcine surfactant were 45% via endotracheal tube and 14% via nasal-continuous positive airway pressure (prongs). These figures might be physiologically relevant, but still have to be confirmed in efficacy studies.<\/jats:p>","DOI":"10.1159\/000369955","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T09:01:10Z","timestamp":1425373270000},"page":"277-282","source":"Crossref","is-referenced-by-count":35,"title":["Lung Deposition of Nebulized Surfactant in Newborn Piglets"],"prefix":"10.1159","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9178-8686","authenticated-orcid":false,"given":"Rikard","family":"Linner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Perez-de-Sa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Cunha-Goncalves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,3,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000349928"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.03.022"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199606000-00005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.2.8756808"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199709)24:3<222::AID-PPUL9>3.0.CO;2-O"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/080352500750028195"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2009.0758"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/fn.78.1.F3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.3.5.693"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22838"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10091989"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2012.05.089"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.24"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/fn.72.2.F84"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050458"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2012.1Su4"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2011.05.006"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/B0-12-370879-6\/00019-3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00096.2009"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-774OC"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198309000-00012"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200007000-00058"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/369955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/369955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:07:47Z","timestamp":1745431667000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000369955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,6,1]]},"published-print":{"date-parts":[[2015,6,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000369955","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}