{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:09:20Z","timestamp":1776323360131,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Background:<\/i><\/b> Testing metabolic effects of a novel calcium-free, magnesium, phosphate and lactate containing solution (Lactocitrate) in combination with citrate anticoagulation. <b><i>Methods:<\/i><\/b> Patients on CRRT (2,000 ml\/h, blood flow (Qb) 100 ml\/min, trisodium citrate (4% TSC)) with arterial lactate <3 mmol\/l were included. At start, bicarbonate-buffered fluid was changed to Lactocitrate and the substitution of magnesium and phosphorus ceased. At 9 h the Qb was increased to 150 ml\/min. At 18 h the CRRT dosage was increased to 3,000 ml\/h. <b><i>Results: <\/i><\/b>In 22 CVVHDF patients and another 23 on CVVH the pH, aHCO<sub>3<\/sub> and Na (all p > 0.05) showed no significant changes regardless of the increased dosage of 4% TSC at 9 h (p < 0.001). Mg<sub>tot<\/sub> and phosphorus stabilised within normal range. Arterial lactate increased to 1.9 (1.6-2.6) mmol\/l at 3,000 ml\/h, p < 0.001). Citrate- and lactate-related energetic gains were up to 74 (61-86) kJ\/h. <b><i>Conclusions:<\/i><\/b> The fluid performed well within ordinary CRRT dosage and Qb up to 150 ml\/min. Lactate levels mildly increased and no magnesium and phosphorus replenishments were necessary.<\/jats:p>","DOI":"10.1159\/000369956","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T07:38:21Z","timestamp":1421048301000},"page":"263-272","source":"Crossref","is-referenced-by-count":7,"title":["The Effects of a Novel Calcium-Free Lactate Buffered Dialysis and Substitution Fluid for Regional Citrate Anticoagulation - Prospective Feasibility Study"],"prefix":"10.1159","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1864-2143","authenticated-orcid":false,"given":"Martin","family":"Balik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Zakharchenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Leden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Otahal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Rulisek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Brodska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Stritesky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,1,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/10.1038\/kisup.2012.6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2012.06.003"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/cc13793"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.09.014"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000087770"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000334641"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000088177"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000060867.17556.A0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr075"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(03)00107-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052521"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/cc9358"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0754-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-002-0963-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181a00a92"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr106"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802639"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0902413"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1812-1"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2251-3"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/369956","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/369956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:07:47Z","timestamp":1745431667000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000369956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":20,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2015,2,1]]},"published-print":{"date-parts":[[2015,2,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000369956","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}