{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T11:34:20Z","timestamp":1769340860315,"version":"3.49.0"},"reference-count":11,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Actinic keratosis (AK), a frequently diagnosed cutaneous neoplasm in individuals with chronic sun exposure or fair skin, is a risk factor for squamous cell carcinoma. AK presents as clinically visible lesions and\/or as subclinical lesions where an entire field of area (field cancerization) contains lesions of various grades. The diagnosis and surveillance of subclinical AK is challenging. We report a new AK management approach, including subclinical AK, with noninvasive in vivo reflectance confocal microscopy (RCM) monitoring of field-directed topical 5-fluorouracil 0.5%\/salicylic acid 10.0% (5-FU\/SA; currently approved for single lesions). In this case series, eight patients with primarily recurrent, multiple AKs received \u22646 weeks of field-directed 5-FU\/SA; complete clearance of clinical\/subclinical AKs on various body areas was shown in most patients using RCM. RCM facilitated the detection\/characterization of subclinical AKs in the setting of field cancerization. Topical field-directed 5-FU\/SA monitored with RCM is a promising management approach for subclinical AKs.<\/jats:p>","DOI":"10.1159\/000370148","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T10:59:18Z","timestamp":1424084358000},"page":"193-198","source":"Crossref","is-referenced-by-count":25,"title":["In vivo Reflectance Confocal Microscopy Characterization of Field-Directed 5-Fluorouracil 0.5%\/Salicylic Acid 10% in Actinic Keratosis"],"prefix":"10.1159","volume":"230","author":[{"given":"Martina","family":"Ulrich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivette","family":"Alarcon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Malvehy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Puig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,2,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.103342"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.34117.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.9.1216"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07860.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2012.716039"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10387.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2008.00443.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.105565"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.0202a10"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000254893"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70113-G"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/370148","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/370148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:09:34Z","timestamp":1745431774000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000370148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,1]]},"published-print":{"date-parts":[[2015,3,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000370148","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}