{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:33:32Z","timestamp":1745469212052,"version":"3.40.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to evaluate the expression of cyclooxygenase 2 (COX-2) and its association with the development of premalignant lesions in gland structures of the endometrium in patients with uterine prolapse, a condition which exposes the uterus to mechanical and infectious stress. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The study included 102 patients who underwent hysterectomy to correct grade 3-4 uterine prolapse and 105 patients who underwent hysterectomy for other causes. Endometrial gland structures underwent immunohistochemical staining and COX-2 expression was graded. Grades 0 and 1 represent low expression; grades 2 and 3 correspond to high levels of COX-2 expression. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The prevalence of grade 2-3 COX-2 expression was significantly higher in the endometrial gland structures of patients with prolapse and hyperplasia compared to the remaining patients (p = 0.014). Grade 0-1 COX-2 expression was significantly more common in the endometrial gland structures of patients without uterine prolapse or hyperplasia (p = 0.004). Among the patients without endometrial hyperplasia, COX-2 expression was elevated in the endometrial gland structures of those with uterine prolapse compared to those without prolapse. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Elevated COX-2 expression may explain the presence of unexpected premalignant lesions of the endometrium in patients with uterine prolapse.<\/jats:p>","DOI":"10.1159\/000371348","type":"journal-article","created":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T07:48:31Z","timestamp":1423122511000},"page":"119-123","source":"Crossref","is-referenced-by-count":0,"title":["Does Uterine Prolapse Alter Endometrial Cyclooxygenase 2 Expression and Promote the Development of Premalignant Lesions?"],"prefix":"10.1159","volume":"80","author":[{"given":"Mine","family":"Genc","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oya Nermin","family":"Sivrikoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esin","family":"Celik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guluzar Arzu","family":"Turan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serkan","family":"Guclu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,2,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s001920170062"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000343230"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181b0c2ae"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000341709"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000360135"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v4.i3.62"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-10-0072"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25840"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-10-0053"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-1222"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)01220-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70243-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.02.010"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01179.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2011.01337.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.01.077"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.05.011"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000339933"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00058-6"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4065"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0493"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/371348","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/371348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/371348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:11:58Z","timestamp":1745431918000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000371348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,8,1]]},"published-print":{"date-parts":[[2015,8,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000371348","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"type":"print","value":"0378-7346"},{"type":"electronic","value":"1423-002X"}],"subject":[],"published":{"date-parts":[[2015]]}}}