{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T08:24:44Z","timestamp":1775291084871,"version":"3.50.1"},"reference-count":27,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Obstructive sleep apnoea (OSA) has interdependently been related to the onset and progression of a large portion of atherosclerotic cardiovascular disorders. In due consideration of OSA-mediated endothelial dysfunction, its impact on peripheral artery disease is conceivable, but undefined. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to identify the prevalence of OSA in a lower extremity artery disease (LEAD) study population. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A total of 91 patients receiving in- and outpatient treatment for LEAD were included in this prospectively conducted trial. In addition to an angiological examination, all patients underwent nocturnal screening for sleep-disordered breathing by use of SOMNOcheck micro\u00ae (SC micro) and - depending on the results obtained - polysomnography. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Patients were principally late middle-aged (69.3 \u00b1 10.8 years), male (71.4%) and slightly overweight (BMI 26.8 \u00b1 3.9). Overnight screening determined a sleep apnoea prevalence of 78.0%, of which 90.1% exhibited a predominantly obstructive genesis. The mean apnoea-hypopnoea index (AHI; events\/h) and oxygen desaturation index (events\/h) averaged 11.8 \u00b1 13.4 and 8.9 \u00b1 14.2, respectively. The individual AHI categories of non-pathological (&lt;5), mild (5 to &lt;15), moderate (15 to &lt;30) and severe sleep apnoea (\u226530) accounted for 22.0, 59.3, 13.2 and 5.5%, respectively. A distributive examination of AHI within LEAD severity groups evinced a significant association (p = 0.047). In cases of at least moderate sleep apnoea (AHI \u226515) polysomnography was performed (n = 17, 18.7% of the whole collective). Correlative analysis revealed a significant correlation between values obtained by SC micro recording and polysomnography, establishing the diagnostic accuracy of the screening results. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; OSA exhibits an important prevalence of 70.3% in LEAD patients with prior undiagnosed sleep-disordered breathing, indicating major OSA unawareness in this cardiovascular cohort. However, the impact of OSA treatment on LEAD propagation remains to be determined.<\/jats:p>","DOI":"10.1159\/000371355","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T09:23:51Z","timestamp":1424769831000},"page":"214-220","source":"Crossref","is-referenced-by-count":20,"title":["Underdiagnosis of Obstructive Sleep Apnoea in Peripheral Arterial Disease"],"prefix":"10.1159","volume":"89","author":[{"given":"Carmen","family":"Pizarro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Kimeu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Pingel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fritz","family":"Horlbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"Tuleta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Nickenig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Skowasch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr211"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1326.2002.0040s20s1.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000128519.60762.84"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000137913.26087.F0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/0003319708325445"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.16.2013"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200306-767OC"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000342877"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2007.08.002"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00227611"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2006.05173.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000342010"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2148"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2172"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2336"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00172211"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000018948.95175.03"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000089091.09527.B8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.7.2104126"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000153794.52852.04"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.741512"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000358442"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9048(03)00090-9"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-005-0017-y"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws342"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft051"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/371355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/371355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:12:07Z","timestamp":1745431927000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000371355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,1]]},"published-print":{"date-parts":[[2015,3,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000371355","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}