{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:34:48Z","timestamp":1789706088640,"version":"4.0.1"},"reference-count":27,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sex Dev"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>In 4 complete androgen insensitivity syndrome (CAIS) members of one family, 2 presented extreme and unusual clinical features: male gender identity disorder (case 1) and female precocious central puberty (case 2). The &lt;i&gt;AR &lt;\/i&gt;gene carried the mutation c.1752C&gt;G, p.Phe584Leu. Gender dysphoria in CAIS may be considered as a true transgender and has been described in 3 other cases. Central precocious puberty has only been described in 1 case; M\u00fcllerian ducts in case 2 permitted menarche. Despite the common CAIS phenotype, there was a familial disparity for gender identity adequacy and timing and type of puberty.<\/jats:p>","DOI":"10.1159\/000371617","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T07:40:06Z","timestamp":1422517206000},"page":"75-79","source":"Crossref","is-referenced-by-count":18,"title":["Complete Androgen Insensitivity Syndrome Associated with Male Gender Identity or Female Precocious Puberty in the Same Family"],"prefix":"10.1159","volume":"9","author":[{"given":"Jos\u00e9 A.","family":"Berm\u00fadez de la Vega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Fern\u00e1ndez-Cancio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Bernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Aud\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2146"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-011-9823-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1575-0922(08)75845-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(05)70346-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2002.15.9.1553"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0243-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/00224490701586730"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.11.020"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10340"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22046"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2000-s619"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2014.09.013"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022492106974"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2007.01.001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.3.303"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-009-9526-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-005-4341-x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-009-9533-3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2013.05.011"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.09.027"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.29.8.539"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000091592"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000363628"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1080\/00224490902898728"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-010-9624-1"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.8.6742"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)81043-5"}],"container-title":["Sexual Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/371617","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/371617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:14:42Z","timestamp":1745432082000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000371617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,3,1]]},"published-print":{"date-parts":[[2015,3,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000371617","archive":["Portico"],"relation":{},"ISSN":["1661-5425","1661-5433"],"issn-type":[{"value":"1661-5425","type":"print"},{"value":"1661-5433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}