{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:32:24Z","timestamp":1791639144490,"version":"4.3.4"},"reference-count":183,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T00:00:00Z","timestamp":1420761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T00:00:00Z","timestamp":1420761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Pituitary adenomas are a common feature of a subset of endocrine neoplasia syndromes, which have otherwise highly variable disease manifestations. We provide here a review of the clinical features and human molecular genetics of multiple endocrine neoplasia (MEN) type 1 and 4 (MEN1 and MEN4, respectively) and Carney complex (CNC). MEN1, MEN4, and CNC are hereditary autosomal dominant syndromes that can present with pituitary adenomas. MEN1 is caused by inactivating mutations in the &lt;i&gt;MEN1&lt;\/i&gt; gene, whose product menin is involved in multiple intracellular pathways contributing to transcriptional control and cell proliferation. MEN1 clinical features include primary hyperparathyroidism, pancreatic neuroendocrine tumours and prolactinomas as well as other pituitary adenomas. A subset of patients with pituitary adenomas and other MEN1 features have mutations in the &lt;i&gt;CDKN1B&lt;\/i&gt; gene; their disease has been called MEN4. Inactivating mutations in the type 1\u03b1 regulatory subunit of protein kinase A (PKA; the &lt;i&gt;PRKAR1A&lt;\/i&gt; gene), that lead to dysregulation and activation of the PKA pathway, are the main genetic cause of CNC, which is clinically characterised by primary pigmented nodular adrenocortical disease, spotty skin pigmentation (lentigines), cardiac and other myxomas and acromegaly due to somatotropinomas or somatotrope hyperplasia.<\/jats:p>","DOI":"10.1159\/000371819","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T07:38:38Z","timestamp":1421048318000},"page":"18-31","source":"Crossref","is-referenced-by-count":87,"title":["MEN1, MEN4, and Carney Complex: Pathology and Molecular Genetics"],"prefix":"10.1159","volume":"103","author":[{"given":"Marie 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