{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:17:18Z","timestamp":1777544238209,"version":"3.51.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background:<\/i><\/b> Nocturnal<b> <\/b>adaptive servoventilation (ASV) therapy is now frequently used to treat Cheyne-Stokes respiration (CSR), which is highly prevalent in patients with moderate-to-severe heart failure (HF) and characterized by periodical breathing (hyperventilation). <b><i>Objectives:<\/i><\/b> This study analyzed and compared the acute effects of a novel ASV device on carbon dioxide pressure (pCO<sub>2<\/sub>) and oxygen saturation (SaO<sub>2<\/sub>) in HF patients with CSR and healthy volunteers. The influence of being asleep or awake on the ASV algorithm was also determined. <b><i>Methods:<\/i><\/b> All subjects underwent ASV (PaceWave\u2122, ResMed) for 1 h. Transcutaneous pCO<sub>2<\/sub> (PtcCO<sub>2<\/sub>) and SaO<sub>2<\/sub> were assessed transcutaneously, while wakefulness was analyzed using EEG recordings. Assessments were made 30 min before and after ASV, and during 1 h of ASV. <b><i>Results:<\/i><\/b> Twenty HF patients (19 male; age 79 \u00b1 12 years) and 15 volunteers (13 male, age 25 \u00b1 4 years) were included. When awake, ASV was associated with a trend towards a decrease in PtcCO<sub>2<\/sub> and an increase in SaO<sub>2<\/sub> versus baseline in HF patients (34.4 \u00b1 3.2 to 33.7 \u00b1 3.8 mm Hg and 93.8 \u00b1 2.6 to 94.9 \u00b1 2.6%, respectively) and volunteers (39.5 \u00b1 3.0 to 38.2 \u00b1 3.8 mm Hg and 96.9 \u00b1 1.3 to 97.8 \u00b1 0.9%). While asleep during ASV, PtcCO<sub>2<\/sub> increased to 36.3 \u00b1 3.8 mm Hg and SaO<sub>2<\/sub> decreased to 93.8 \u00b1 2.6% in HF patients, with similar changes in volunteers (PtcCO<sub>2<\/sub> 41.7 \u00b1 3.0 mm Hg, SaO<sub>2<\/sub> 97.1 \u00b1 1.2). All comparisons were statistically significant (p \u2264 0.05, except the PtcCO<sub>2<\/sub> decrease in both groups when awake). <b><i>Conclusions:<\/i><\/b> ASV therapy might result in hyperventilation when subjects are awake, but while asleep, PtcCO<sub>2<\/sub> increased to mid-normal values, effects that would be favorable in HF patients with CSR.<\/jats:p>","DOI":"10.1159\/000375312","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T21:02:46Z","timestamp":1428613366000},"page":"374-382","source":"Crossref","is-referenced-by-count":9,"title":["Respiratory Effects of Adaptive Servoventilation Therapy in Patients with Heart Failure and Cheyne-Stokes Respiration Compared to Healthy Volunteers"],"prefix":"10.1159","volume":"89","author":[{"given":"Jens","family":"Spie\u00dfh\u00f6fer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Efken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bitter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"K\u00f6rber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Horstkotte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Oldenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2006.08.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328312ed61"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-12-0689"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.5.9810040"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200927"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-014-0784-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft051"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2007.09.008"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.4.9908114"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e32835364b2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-014-1083-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-010-0216-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2172"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-011-0575-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00218.2011"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2004.028985"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(98)00070-X"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.2.330"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.4.1079"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1173"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1515\/bmte.2003.48.6.170"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/375312","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/375312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:41:28Z","timestamp":1745430088000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000375312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,1]]},"published-print":{"date-parts":[[2015,5,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000375312","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}