{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:31:30Z","timestamp":1745469090776,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement Med Res"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Hintergrund:<\/i><\/b> Viele hom\u00f6opathische Arzneimittel werden auch f\u00fcr die Behandlung parodontaler Entz\u00fcndungsprozesse eingesetzt. \u00dcber deren Wirkprinzipien ist allerdings nur wenig bekannt. Ziel dieser Studie war es daher, die Effekte verd\u00fcnnter Substanzen auf die Migrationsaktivit\u00e4t von Lymphozyten bei parodontalen Entz\u00fcndungsprozessen in vitro zu untersuchen. <b><i>Material und Methoden:<\/i><\/b> Lymphozyten wurden aus Blutproben von 3 Parodontitispatienten und 3 gematchten gesunden Probanden extrahiert und zusammen mit verd\u00fcnnten w\u00e4ssrigen Extrakten (D12 and C200) von Mercurius solubilis, Silicea, Sulfur, Tuberculinum oder Placebo in eine Kollagenmatrix eingebettet. Nach einer 60-min\u00fctigen mikroskopischen Videoaufzeichnung im Zeitraffer wurden die Migrationsaktivit\u00e4t und -geschwindigkeit der Lyphozyten von je 30 randomisiert ausgew\u00e4hlten Zellen nachvollzogen. Neben univariaten statistischen Verfahren wurde eine SiZer-Zeitreihenanalyse durchgef\u00fchrt. <b><i>Ergebnisse:<\/i><\/b> W\u00e4hrend bei den Hochverd\u00fcnnungen (C200) keine bedeutenden Unterschiede zwischen Placebo und den Substanzen gefunden wurden, konnten bei den niedrigen Verd\u00fcnnungen (D12) im Vergleich zu Placebo starke Effekte beobachtet werden. Die st\u00e4rksten Effekte wurden in den mit Sulfur D12 exponierten Lyphozyten beobachtet. W\u00e4hrend bei den Lymphozyten der Parodontitispatienten ein spezifischer Aktivierungseffekt (mittlere Aktivit\u00e4t: 11,1% (Placebo) vs. 23,8% (Verum)) festgestellt werden konnte, blieb dieser bei den gesunden Probanden aus (25,8% (Placebo) vs. 25,6% (Verum)). Dieser Effekt konnte auch durch die SiZer-Zeitreihenanalyse als signifikant best\u00e4tigt werden. <b><i>Schlussfolgerung:<\/i><\/b> Die Debatte um die Wirkprinzipien von hochverd\u00fcnnten Substanzen wird immer noch kontrovers gef\u00fchrt. Trotz der geringen Teilnehmerzahl und den damit verbundenen Limitierungen in der Aussagekraft sind insbesondere die Ergebnisse f\u00fcr Sulfur D12 ermutigend. Diese sollten in nachfolgenden Experimenten \u00fcberpr\u00fcft und durch weitere immunologische Versuche wie z.B. die Durchflusszytometrie von Zellinien verifiziert werden.<\/jats:p>","DOI":"10.1159\/000375328","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T13:28:04Z","timestamp":1458653284000},"page":"10-17","source":"Crossref","is-referenced-by-count":1,"title":["Lymphozytenmigration unter Exposition hom\u00f6opathischer Arzneimittel bei parodontaler Entz\u00fcndung - eine kontrollierte Pilotstudie"],"prefix":"10.1159","volume":"22","author":[{"given":"Georg","family":"Gassmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christa","family":"Raak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"B\u00fcchel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Schaupp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Entschladen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Friedmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Ostermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1242562"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2013.05.002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nek018"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080612"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-10-62"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302X.2002.170609.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-997-0129-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2010.202"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.homp.2011.05.005"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-817648"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jspi.2009.05.003"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2011.0205"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/10446670410001722203"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(73)90584-3"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00481-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.homp.2004.07.004"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3109\/08923970009016409"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.17.1981"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-2299(99)80006-5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4025\/actasciagron.v31i1.6642"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-0785(05)80655-6"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21723"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1198\/016214505000001294"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-11-24"}],"container-title":["Complementary Medicine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/375328","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/375328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:41:41Z","timestamp":1745430101000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000375328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000375328","archive":["Portico"],"relation":{},"ISSN":["2504-2092","2504-2106"],"issn-type":[{"type":"print","value":"2504-2092"},{"type":"electronic","value":"2504-2106"}],"subject":[],"published":{"date-parts":[[2015]]}}}