{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:45:08Z","timestamp":1762004708511,"version":"3.40.4"},"reference-count":27,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Background and Aim:<\/i><\/b> Tigecycline is a semi-synthetic tetracycline with activity against most multidrug-resistant (MDR) bacteria. <b><i>Methods:<\/i><\/b> We studied in vitro activity of tigecycline by agar dilution (AD) and Etest methods to evaluate their correlation. The study included 206 isolates of extended-spectrum \u03b2-lactamase (ESBL)-producing <i>Escherichia coli, Klebsiella pneumoniae<\/i> and MDR <i>Acinetobacter baumannii<\/i> recovered from blood cultures of patients of Baskent University between 2008 and 2010. <b><i>Results:<\/i><\/b> ESBL-producing <i>E. coli<\/i> had MIC<sub>50<\/sub>\/MIC<sub>90<\/sub> values of 0.5\/0.5 \u00b5g\/ml by AD and 0.25\/0.5 \u00b5g\/ml by Etest. ESBL-producing <i>K. pneumoniae<\/i> had MIC<sub>50<\/sub>\/MIC<sub>90<\/sub> values of 1\/2 \u00b5g\/ml by AD and 0.75\/2 \u00b5g\/ml by Etest, whereas MDR <i>A. baumannii<\/i> had MIC<sub>50<\/sub>\/MIC<sub>90<\/sub> values of 4\/4 \u00b5g\/ml by AD and 2\/4 \u00b5g\/ml by Etest. The correlation between AD and Etest was weak for ESBL-producing <i>E. coli<\/i> and strong for ESBL-producing <i>K. pneumoniae<\/i> and MDR <i>A. baumannii. <\/i>Tigecycline MIC values for ESBL-producing <i>E. coli<\/i> were lower than the tigecycline concentration, while they were higher than the concentrations attainable by treatment doses for <i>A. baumannii<\/i>. <b><i>Conclusion:<\/i><\/b> Tigecycline is an appropriate agent in the treatment of <i>E. coli<\/i> bacteremia, but it is not for treating <i>A. baumannii<\/i> bacteremia. Tigecycline could be used for <i>K. pneumoniae<\/i> bacteremia treatment after determining its MIC value. Determining the MIC value by gold-standard methods is more appropriate due to the correlation between Etest and AD at high MIC values.<\/jats:p>","DOI":"10.1159\/000375440","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T07:36:03Z","timestamp":1426059363000},"page":"151-156","source":"Crossref","is-referenced-by-count":7,"title":["In vitro Susceptibility of Tigecycline against Multidrug-Resistant Gram-Negative Strains: Etest versus Agar Dilution"],"prefix":"10.1159","volume":"60","author":[{"given":"Sezen","family":"\u00d6zk\u00f6k","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turhan","family":"Togan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015feg\u00fcl","family":"Yesilkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Funda","family":"Timurkaynak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zlem Kurt","family":"Azap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hande","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,3,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13644-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080\/00365540410019156"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1086\/513640"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki248"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.11.001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis270"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp169"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00119-10"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki386"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02464-08"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4479-4481.2004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.10.020"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.05.004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-9-44"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1086\/431675"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1086\/431676"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.06.001"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2004.11.006"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.05.005"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(01)00269-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00210-06"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00322-06"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.02.018"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm018"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.04.002"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00637-08"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(08)70024-4"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/375440","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/375440","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/375440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:42:18Z","timestamp":1745430138000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000375440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,4,1]]},"published-print":{"date-parts":[[2015,4,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000375440","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[2014]]}}}