{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T19:51:16Z","timestamp":1775073076540,"version":"3.50.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background:<\/i><\/b> Classifying the severity of bronchopulmonary dysplasia (BPD) by continuous numerical variables would facilitate follow-up of disease progression and quantified analysis of disease determinants. <b><i>Objectives:<\/i><\/b> To non-invasively measure oxygenation impairment in BPD by the degree of right-to-left shunt, right shift of the oxyhaemoglobin dissociation curve and ventilation\/perfusion (V<sub>A<\/sub>\/Q) inequality and to explore their relation with clinical parameters. <b><i>Methods:<\/i><\/b> Prospective cohort study of 24 infants with a median (interquartile range, IQR) gestation of 25 weeks (24-27) and a birth weight of 0.70 kg (0.63-0.93), studied at 36 days (30-66), at a postmenstrual age (PMA) of 33 weeks (29-36). Inspired oxygen (F<sub>I<\/sub>O<sub>2<\/sub>) was varied to obtain three to five transcutaneous oxygen saturation (SpO<sub>2<\/sub>) values between 85 and 96%. Values of shunt, shift and V<sub>A<\/sub>\/Q were obtained by plotting the paired data of SpO<sub>2<\/sub> against F<sub>I<\/sub>O<sub>2<\/sub> for each infant using a unique program. Right-to-left shunt, right shift of the oxyhaemoglobin dissociation curve and V<sub>A<\/sub>\/Q were measured in infants born <32 weeks PMA receiving oxygen at 28 days. <b><i>Results:<\/i><\/b> The median (IQR) shunt was 8% (0.3-16.5), shift 14.5 kPa (10.9-19.4) and V<sub>A<\/sub>\/Q 0.40 (0.30-0.48). Shunt, shift and V<sub>A<\/sub>\/Q were significantly related to gestational age (GA) at birth, PMA at study, weight at study and weight gain per week. <b><i>Conclusions:<\/i><\/b> Severity of pulmonary oxygenation impairment in BPD can be quantified at the cot-side by non-invasive measurement of shunt, shift and V<sub>A<\/sub>\/Q. Low GA at birth, low weight at birth and at the time of study and impaired weight gain are significantly associated with the severity of oxygen-exchange impairment in infants with BPD.<\/jats:p>","DOI":"10.1159\/000376567","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T09:01:10Z","timestamp":1425373270000},"page":"283-288","source":"Crossref","is-referenced-by-count":38,"title":["Using Measurements of Shunt and Ventilation-to-Perfusion Ratio to Quantify the Severity of Bronchopulmonary Dysplasia"],"prefix":"10.1159","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-5301","authenticated-orcid":false,"given":"Theodore","family":"Dassios","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Curley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Morley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Ross-Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,3,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3283423e6b"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23235"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.01.047"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2013.01.009"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.140830"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000297771"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1806OC"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000336030"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196702162760701"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/71.4.488"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/fn.85.2.F127"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.095406"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-3249"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004454.pub2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.11.026"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7976"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.18"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1295646"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050605"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01959.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.11.036"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22751"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110602"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/376567","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/376567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:44:27Z","timestamp":1745430267000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000376567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,6,1]]},"published-print":{"date-parts":[[2015,6,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000376567","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}