{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:29:39Z","timestamp":1758479379346,"version":"3.40.5"},"reference-count":19,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Objective:<\/i><\/b> To evaluate the feasibility of tracheo-amniotic shunting in a sheep model for congenital high airway obstruction syndrome. <b><i>Material and Methods:<\/i><\/b> High airway obstruction was induced around day 95 (term = 145 days) in 10 lamb fetuses by tracheal clipping. Five days later, ultrasound-guided tracheoamniotic shunting was done using either the Harrison double-pigtail bladder stent (HS) or a double-basket device (BS). Caesarean section (CS) was done around day 110. At each time point, the cardiothoracic index (CTI) was measured. Lung-to-body weight ratio (LBWR) was calculated at fetal necropsy. The primary endpoint was successful shunting defined as anatomically correct placement and functional airway decompression; the secondary endpoint was survival until CS. <b><i>Results:<\/i><\/b> Two sheep aborted 3 fetuses after tracheal occlusion. Overall, the median CTI at CS was significantly smaller compared to baseline [0.52 (interquartile range, IQR: 0.52-0.54) vs. 0.58 (IQR: 0.54-0.63); p = 0.01]. In the HS group (n = 4), none of the shunts were correctly positioned. In the BS group (n = 3), there was 1 correct shunt placement; however, this fetus was stillborn. Median LBWR suggested pulmonary overgrowth [0.10 (IQR: 0.08-0.11)]. <b><i>Conclusion:<\/i><\/b> In our hands, using this model with a long and mobile neck and relative oligohydramnios, tracheoamniotic shunting for airway obstruction has a high failure rate. If further pursued, alternative techniques or different models should be considered.<\/jats:p>","DOI":"10.1159\/000381145","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T00:10:00Z","timestamp":1429229400000},"page":"282-287","source":"Crossref","is-referenced-by-count":2,"title":["Experimental Evaluation of Tracheo-Amniotic Shunting for Induced Congenital High Airway Obstruction in a Sheep Model"],"prefix":"10.1159","volume":"38","author":[{"given":"Philip","family":"DeKoninck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Endo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-945X","authenticated-orcid":false,"given":"Jan A.","family":"Deprest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5287-9673","authenticated-orcid":false,"given":"Luc","family":"De Catte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,4,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(94)90331-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199802000-00005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80326-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000242454"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(03)00128-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000305096"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370433"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90500-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000021022"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000063179"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/uog.899"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.01.022"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1974"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000200017"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000350697"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(98)00183-3"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90451-1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080\/00016340500449923"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000078994"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:50:25Z","timestamp":1745430625000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000381145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,12,1]]},"published-print":{"date-parts":[[2015,12,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000381145","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2015]]}}}