{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:45:33Z","timestamp":1780058733636,"version":"3.54.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T00:00:00Z","timestamp":1429660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T00:00:00Z","timestamp":1429660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background and Aims:&lt;\/i&gt;&lt;\/b&gt; Two types of epithelial ovarian carcinoma (EOC) have been recently distinguished. Type I comprises low-grade serous, endometrioid and clear-cell tumors. High-grade endometrioid and serous tumors belong to type II. The aim of this study was to compare patterns of disease spread in advanced-stage type I and II EOCs at primary surgery. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Surgical and pathological data of 233 patients with advanced-stage EOCs were collected, 42 with type I and 191 with type II. The two groups were compared for tumor localization at primary surgery. Intraoperative mapping of ovarian cancer (IMO) was used to assess tumor dissemination. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Tumor involvement was significantly higher in the type II group for the following: peritoneum (68.1 vs. 40.5%, p &lt; 0.001), pouch of Douglas (60.2 vs. 40.5%, p = 0.06), vesicouterine ligament (40.8 vs. 19%, p = 0.027), diaphragm (45.0 vs. 11.9%, p &lt; 0.001), serosa of liver (17.2 vs. 4.8%, p = 0.05), omentum (81.1 vs. 59.5%, p = 0.007), mesentery (42.9 vs. 16.7%, p = 0.005), pleural effusions (19.4 vs. 4.6%, p = 0.01) and ascites (60.7 vs. 21.4%, p &lt; 0.001). IMO levels were different between the two groups (p = 0.001). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; This study provides clinical evidence in favor of the dualistic model of carcinogenesis, since types I and II are characterized by different findings at primary surgery.<\/jats:p>","DOI":"10.1159\/000381261","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T21:03:14Z","timestamp":1429736594000},"page":"10-14","source":"Crossref","is-referenced-by-count":7,"title":["Different Patterns of Disease Spread between Advanced-Stage Type I and II Epithelial Ovarian Cancer"],"prefix":"10.1159","volume":"81","author":[{"given":"Alice","family":"Bergamini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Candiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Taccagni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Rabaiotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Vigan\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"De Marzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Mangili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.03.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2696"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63708-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196333"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-41864"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.07.032"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.10.856"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-012-1203-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.05.007"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000357819"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.02.034"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804690"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/path.1000"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.02.012"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.07.123"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.08.025"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.1027"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70090-7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199502000-00002"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00278-6"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.05.032"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2006.08.021"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000214"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.09.006"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000349894"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381261","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:51:59Z","timestamp":1745430719000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000381261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,22]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000381261","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,22]]}}}