{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:11:10Z","timestamp":1773285070494,"version":"3.50.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Leiomyomatosis peritonealis disseminata (LPD) is a rare disease characterised by the subperitoneal proliferation of smooth muscle cells that form benign nodules. A few studies have aimed to reveal the pathogenesis of LPD without reaching a clear explanation. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Karyotype analysis and array-comparative genomic hybridization (aCGH) of a human LPD case were performed to evaluate the role of chromosomal abnormalities in LPD pathogenesis. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The LPD nodules showed a 45, XX, del(7p), t(11; 17) (q23;q25),-22 de novo karyotype, and the aCGH analysis confirmed these deletions at 7p22.3-p12.1 (1,862,362-52,766,911 bp) and 22q11.23-q13.33 (21,973,915-49,265,116 bp) with lengths of 50.9 Mb and 27.3 Mb, respectively. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; In this study, we described two large novel aberrations - deletions in chromosome 7 and 22 - that might play an important role in LPD disease. These findings might contribute to new insights to unravel the pathogenesis of LPD and develop further clinical treatments.<\/jats:p>","DOI":"10.1159\/000381262","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T21:01:23Z","timestamp":1430168483000},"page":"186-192","source":"Crossref","is-referenced-by-count":1,"title":["A Novel Molecular Cytogenetic Finding of Leiomyomatosis Peritonealis Disseminata"],"prefix":"10.1159","volume":"81","author":[{"given":"Yan-Ting","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song-Chang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Wei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Ming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang-Mei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(93)90528-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(99)00203-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000164949"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4103\/0300-1652.104390"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4137\/CCRep.S9530"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.17772\/gp\/1544"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20824"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.01.074"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/74052430"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000274487"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gap050"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.07.017"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(00)00225-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(93)90195-R"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000347017"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2003.01452.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.09.007"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1540407"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00541.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-0748-5"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-127"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000360083"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318180219b"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381262","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:52:00Z","timestamp":1745430720000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000381262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,23]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,3,1]]},"published-print":{"date-parts":[[2016,3,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000381262","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5127817","asserted-by":"subject"}]},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,23]]}}}