{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:02:06Z","timestamp":1790067726114,"version":"4.0.1"},"reference-count":37,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background:<\/i><\/b> Information on the role of fungi in non-cystic fibrosis (CF) bronchiectasis is lacking. <b><i>Objectives:<\/i><\/b> Our aim was to determine the prevalence of and factors associated with the isolation and persistence of fungi from sputum in these patients. <b><i>Methods:<\/i><\/b> We performed a multicenter observational study comprising adult patients with non-CF bronchiectasis. Persistence of <i>Aspergillus <\/i>spp. and <i>Candida albicans<\/i> was defined as the presence of \u22652 positive sputum cultures taken at least 6 months apart within a period of 5 years. <b><i>Results:<\/i><\/b> A total of 252 patients (62.7% women with a mean \u00b1 SD age of 55.3 \u00b1 16.7 years) were included in the study. All patients had at least 1 sputum sample cultured for fungi, with a mean \u00b1 SD of 7 \u00b1 6 cultures per patient. Eighteen (8.7%) and 71 (34.5%) patients had persistent positive cultures for <i>Aspergillus<\/i> spp. and <i>C. albicans<\/i>, respectively. Patients with persistence of <i>Aspergillus <\/i>spp. and <i>C. albicans <\/i>were older and had more daily purulent sputum. In addition, patients with persistent <i>C. albicans <\/i>had worse postbronchodilator forced expiratory volume in the first second (FEV<sub>1<\/sub>), more frequent cystic bronchiectasis, and more hospital-treated exacerbations. They were also more frequently treated with long-term antibiotics. Multivariate analysis showed that daily purulent sputum (OR = 3.75, p = 0.045) and long-term antibiotics (OR = 2.37, p = 0.005) were independently associated with persistence of <i>Aspergillus <\/i>spp. and <i>C. albicans<\/i>, respectively. <b><i>Conclusions:<\/i><\/b> Isolation and persistence of<i> Aspergillus <\/i>spp. and <i>C. albicans <\/i>are frequent in patients with non-CF bronchiectasis. Daily purulent sputum and chronic antibiotic treatment were associated with persistence of <i>Aspergillus <\/i>spp. and <i>C. albicans<\/i>, respectively.<\/jats:p>","DOI":"10.1159\/000381289","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T21:01:23Z","timestamp":1430168483000},"page":"396-403","source":"Crossref","is-referenced-by-count":63,"title":["Prevalence and Factors Associated with Isolation of <b><i>Aspergillus<\/i><\/b> and <b><i>Candida <\/i><\/b>from Sputum in Patients with Non-Cystic Fibrosis Bronchiectasis"],"prefix":"10.1159","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0547-6238","authenticated-orcid":false,"given":"Luis","family":"M\u00e1iz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Vendrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casilda","family":"Olveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Gir\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Nieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Mart\u00ednez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2013.02.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2006.01219.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2996"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1157\/13116602"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202412"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1103"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2009.11.010"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1157\/13128330"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12141"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.8.685"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200104000-00014"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(02)00141-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/723129"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.1.15"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.03.009"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.4.955"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00162912"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136119"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199601)21:1<6::AID-PPUL1>3.0.CO;2-R"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03429.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21240"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1086\/314727"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(99)90270-6"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3109\/13693781003743148"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.13.0838"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.03987.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201001-0087OC"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2010.01971.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.6.9196093"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.3.782"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47705-0"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-006-0422-0"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070784"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.6.7952609"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-1363"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3109\/13693780903127506"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(11)60011-8"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381289","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:52:22Z","timestamp":1745430742000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000381289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":37,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,1]]},"published-print":{"date-parts":[[2015,5,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000381289","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}