{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:32:15Z","timestamp":1745469135261,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Background: Nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) is a rare subtype of Hodgkin's lymphoma showing strong CD20 expression. The role of rituximab in treating NLPHL still needs clarification. Methods: We retrospectively reviewed the outcome of 23 patients with NLPHL treated with rituximab alone or in combination with chemotherapy and\/or radiotherapy as part of their first- or second-line treatment. Results: The median follow-up of the whole group was 67 months, and all patients remained alive. Twenty-two patients achieved complete remission after rituximab-based therapy, and one of them relapsed 32 months after treatment. One patient treated with rituximab alone achieved partial remission and progressed 22 months after treatment. Conclusion: The prognosis of NLPHL is excellent. Rituximab combined with chemotherapy and\/or radiotherapy appears to prevent disease progression\/relapse.<\/jats:p>","DOI":"10.1159\/000381327","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T21:01:26Z","timestamp":1432674086000},"page":"187-192","source":"Crossref","is-referenced-by-count":4,"title":["Can Rituximab Improve the Outcome of Patients with Nodular Lymphocyte-Predominant Hodgkin's Lymphoma?"],"prefix":"10.1159","volume":"134","author":[{"given":"Heidi","family":"Mocikova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Pytlik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavla","family":"Stepankova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozef","family":"Michalka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Markova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Koren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Buresova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludek","family":"Raida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zdenek","family":"Kral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,5,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.8869"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi323"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.0945"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu181"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.3293"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-12-541078"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.9516"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24819"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-515825"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-361055"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.2069"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200310000-00007"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-078725"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq063"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.03.008"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/aha\/article-pdf\/134\/3\/187\/3894686\/000381327.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/aha\/article-pdf\/134\/3\/187\/3894686\/000381327.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:53:04Z","timestamp":1745430784000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000381327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,9,1]]},"published-print":{"date-parts":[[2015,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000381327","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2015]]}}}