{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:59:30Z","timestamp":1778695170694,"version":"3.51.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To document the impact on patient-reported outcomes and health-related quality of life (HRQoL) of treatment with imiquimod cream in patients with actinic keratosis (AK) and superficial basal cell carcinoma (sBCC). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This open-label, multicenter study included AK and sBCC patients eligible for treatment with imiquimod 5% cream. HRQoL was measured by the Skindex-17 and the Skin Cancer Index (SCI) and treatment satisfaction by the Treatment Satisfaction Questionnaire for Medication. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; 118 AK patients and 84 patients with sBCC were included. Low baseline HRQoL impairment was found on both questionnaires, which remained low after treatment, except for a small dip at the end of the application period. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Imiquimod 5% cream treatment has no clinically relevant HRQoL impact in AK and sBCC patients according to the Skindex-17 and SCI. The effect of imiquimod treatment on HRQoL may be limited or these questionnaires do not fully capture relevant issues, such as fear of recurrence.<\/jats:p>","DOI":"10.1159\/000381420","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T21:03:14Z","timestamp":1429736594000},"page":"56-62","source":"Crossref","is-referenced-by-count":15,"title":["Patient Perception of Imiquimod Treatment for Actinic Keratosis and Superficial Basal Cell Carcinoma in 202 Patients"],"prefix":"10.1159","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6163-9164","authenticated-orcid":false,"given":"Rick","family":"Waalboer-Spuij","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Holterhues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"van Hattem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Louise A.","family":"Schuttelaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menno T.W.","family":"Gaastra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dani\u00eblle I.M.","family":"Kuijpers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loes M.","family":"Hollestein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar E.C.","family":"Nijsten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.103342"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.134"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11085.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.431"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.02.022"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2014.2271"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1111170"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08265.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08272.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70143-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2005.00066.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700212"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00082-1"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archfaci.8.5.314"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200302000-00004"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31802e2d88"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.03977.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.11.066"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004415.pub2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10098.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381420","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:54:01Z","timestamp":1745430841000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000381420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,6,1]]},"published-print":{"date-parts":[[2015,6,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000381420","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}