{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:39:32Z","timestamp":1792442372538,"version":"4.5.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Pseudohypoparathyroidism type 1a (PHP1a) is a rare genetic disorder. This study aimed to determine the prevalence of sleep apnea in children with PHP1a. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Nineteen patients with PHP1a between the age of 2 and 21 years were enrolled prospectively using online advertisements. Parents completed a medical history and surveys to assess sleep behavior. Polysomnography records were obtained when available. In addition, 18 subjects were identified in a retrospective chart review of de-identified medical records with 2.3 million patient charts. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Parents reported sleep disturbance (94%) and daytime somnolence (81%) in their children with PHP1a. In the retrospective chart review, 39% had a history of sleep apnea versus 8.8% of a similarly obese control group. In the combined analysis (n = 31), 52% had a history of snoring and 45% had a diagnosis of sleep apnea. Patients were obese with a mean BMI z-score of 2.20 \u00b1 0.59. Patients with sleep apnea were significantly younger than those without a diagnosis (8.1 \u00b1 5.4 vs. 12.8 \u00b1 5.0 years, p = 0.02). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Children with PHP1a have a 4.4-fold greater relative risk of sleep apnea than similarly obese children. Screening for sleep apnea in this population may be warranted to prevent adverse health outcomes.<\/jats:p>","DOI":"10.1159\/000381452","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T21:01:23Z","timestamp":1430168483000},"page":"1-5","source":"Crossref","is-referenced-by-count":15,"title":["Increased Prevalence of Sleep Apnea in Children with Pseudohypoparathyroidism Type 1a"],"prefix":"10.1159","volume":"84","author":[{"given":"Hannah","family":"Landreth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth A.","family":"Malow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1628-3677","authenticated-orcid":false,"given":"Ashley H.","family":"Shoemaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2003.28"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.101089"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3666"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.184"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.17822"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002706"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085918"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2012.02255.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3312"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2226"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2012.09.002"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.03025.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1912"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1497"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1594"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3928\/00904481-20130924-10"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.12.038"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:54:37Z","timestamp":1745430877000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000381452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,8,1]]},"published-print":{"date-parts":[[2015,8,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000381452","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5127856","asserted-by":"subject"}]},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}