{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T04:23:31Z","timestamp":1772511811824,"version":"3.50.1"},"reference-count":27,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stereotact Funct Neurosurg"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Background: At least 14% of Parkinson disease (PD) patients develop impulse control disorders (ICDs). The pathophysiology behind these behaviors and the impact of deep brain stimulation in a real-life setting remain unclear. Objectives: We prospectively examined the impact of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on ICDs in PD patients, as well as the relationship between impaired sensorimotor gaiting and impulsivity. Methods: Patients undergoing bilateral STN-DBS were assessed for ICDs preoperatively and 1-year postoperatively using a validated questionnaire (QUIP-RS). A subset of patients completed the Balloon Analogue Risk Task (BART) and auditory prepulse inhibition (PPI) testing. Results: Analysis revealed 12 patients had an improvement in score assessing ICDs (\u2018good responders'; p = 0.006) while 4 had a worse or stable score (\u2018poor responders'; p &gt; 0.05). Good responders further exemplified a significant decrease in hypersexual behavior (p = 0.005) and binge eating (p = 0.01). Impaired PPI responses also significantly correlated with impulsivity in BART (r = -0.72, p = 0.044). Discussion: Following bilateral STN-DBS, 75% of our cohort had a reduction in ICDs, thus suggesting deep brain stimulation effectively manages ICDs in PD. The role of impaired PPI in predisposition to ICDs in PD warrants further investigation.<\/jats:p>","DOI":"10.1159\/000381558","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T12:19:56Z","timestamp":1434543596000},"page":"265-270","source":"Crossref","is-referenced-by-count":32,"title":["The Influence of Bilateral Subthalamic Nucleus Deep Brain Stimulation on Impulsivity and Prepulse Inhibition in Parkinson's Disease Patients"],"prefix":"10.1159","volume":"93","author":[{"given":"Lucy","family":"Gee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"De La Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joannalee","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Fama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Haller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"Ramirez-Zamora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Durphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Era","family":"Hanspal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Molho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Barba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie G.","family":"Pilitsis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,6,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2217\/npy.11.11"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000341996"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws078"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2012.00029"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1126\/science.1146157"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq301"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2011_195"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.11.018"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100810"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/342151"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1987.tb00302.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-688980-2.50039-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.87.2.175"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22571"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.01.020"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1037\/1076-898X.8.2.75"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1037\/a0023795"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23147"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2008.075820"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21098"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.2.298-a"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000234881.77830.66"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.102061"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2011.00064"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4674-12.2013"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7605-3"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.08.018"}],"container-title":["Stereotactic and Functional Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/sfn\/article-pdf\/93\/4\/265\/3924738\/000381558.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/sfn\/article-pdf\/93\/4\/265\/3924738\/000381558.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:55:28Z","timestamp":1745430928000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000381558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,8,1]]},"published-print":{"date-parts":[[2015,8,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000381558","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5127886","asserted-by":"subject"}]},"ISSN":["1011-6125","1423-0372"],"issn-type":[{"value":"1011-6125","type":"print"},{"value":"1423-0372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}