{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:21:48Z","timestamp":1790245308591,"version":"4.1.0"},"reference-count":36,"publisher":"S. Karger AG","issue":"4-6","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lifestyle Genomics"],"published-print":{"date-parts":[[2014]]},"abstract":"Red meat may increase promutagenic lesions in the colon. Resistant starch (RS) can reduce these lesions and chemically induced colon tumours in rodents. <i>Msh2<\/i> is a mismatch repair (MMR) protein, recognising unrepaired promutagenic adducts for removal. We determined if red meat and\/or RS modulated DNA adducts or oncogenesis in <i>Msh2<\/i>-deficient mice. A total of 100 <i>Msh2<\/i><sup><i>-\/-<\/i><\/sup> and 60 wild-type mice consumed 1 of 4 diets for 6 months: control, RS, red meat and red meat + RS. Survival time, aberrant crypt foci (ACF), colon and small intestinal tumours, lymphoma, colonic O<sup>6<\/sup>-methyl-2-deoxyguanosine (O<sup>6<\/sup>MeG) adducts, methylguanine methyltransferase (MGMT) and cell proliferation were examined. In<i> Msh2<\/i><sup><i>-\/-<\/i><\/sup> mice, red meat enhanced survival compared to control (p < 0.01) and lowered total tumour burden compared to RS (p < 0.167). <i>Msh2<\/i><sup><i>-\/-<\/i><\/sup> mice had more ACF than wild-type mice (p < 0.014), but no colon tumours developed. <i>Msh2<\/i><sup><i>-\/-<\/i><\/sup> increased cell proliferation (p < 0.001), lowered DNA O<sup>6<\/sup>MeG adducts (p < 0.143) and enhanced MGMT protein levels (p < 0.001) compared to wild-type mice, with RS supplementation also protecting against DNA adducts (p < 0.01). No link between red meat-induced promutagenic adducts and risk for colorectal cancer was observed after 6 months' feeding. Colonic epithelial changes after red meat and RS consumption with MMR deficiency will differ from normal epithelial cells.<\/jats:p>","DOI":"10.1159\/000381675","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T11:31:58Z","timestamp":1432812718000},"page":"299-313","source":"Crossref","is-referenced-by-count":4,"title":["Role of Red Meat and Resistant Starch in Promutagenic Adduct Formation, MGMT Repair, Thymic Lymphoma and Intestinal Tumourigenesis in <b><i>Msh2<\/i><\/b>-Deficient Mice"],"prefix":"10.1159","volume":"7","author":[{"given":"Jean M.","family":"Winter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme P.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maija 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