{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:08:00Z","timestamp":1789517280506,"version":"build-2803163510"},"reference-count":18,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; An association between neuroendocrine tumours (NET) and increased risk of developing second primary malignancies (SPM) has been recognised. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This was a retrospective review of our institutional prospectively maintained database of NET patients. We identified patients who had been diagnosed with both neuroendocrine and any additional malignancies via examination of patient notes. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Clinical data for 169 patients were analysed. After exclusion of patients known to have hereditary tumour predisposition syndromes, 29 SPM were identified in 26 patients (15.38%), the commonest being colorectal (n = 6), breast and renal carcinomas (both n = 5). SPM were classified as previous, synchronous or subsequent relative to NET diagnosis. Rates of SPM in pancreatic and small-bowel NET patients were comparable (15.7 vs. 19.6%, p = 0.78). A person-year methodology was used to compare observed numbers of SPM against expected values generated from age- and sex-specific incidence tables, with standardised incidence ratios (SIR) and 95% confidence intervals (CI) calculated. SPM incidence was significantly elevated in the synchronous subset (SIR 2.732, CI 1.177-5.382) whilst significantly fewer NET patients had a cancer history compared to the general population (SIR 0.4, CI 0.241-0.624). No overall differences were evident between observed and expected incidences of subsequent SPM (SIR 0.36, CI 0.044-1.051). The incidence of synchronous colorectal cancers was markedly elevated (SIR 13.079, CI 4.238-30.474). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Our data support the use of colonoscopy in the diagnostic work-up of NET patients in anticipation of a colorectal SPM. The mechanistic underpinnings of this clinical phenomenon require further genetic investigation, and consideration of this knowledge in patient management pathways is warranted.<\/jats:p>","DOI":"10.1159\/000381716","type":"journal-article","created":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T04:12:15Z","timestamp":1427083935000},"page":"26-32","source":"Crossref","is-referenced-by-count":34,"title":["Incidence of Second Primary Malignancies in Patients with Neuroendocrine Tumours"],"prefix":"10.1159","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0061-979X","authenticated-orcid":false,"given":"Ashley K.","family":"Clift","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Drymousis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Al-Nahhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpreet","family":"Wasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sture","family":"Holm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Frilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,3,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.341"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4377"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr533"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu287"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.41"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6119-y"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086414"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-11-0315"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605989"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-013-9911-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-014-1174-x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9098(200012)75:4<306::AID-JSO14>3.0.CO;2-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194911)2:6<1005::AID-CNCR2820020608>3.0.CO;2-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802438495"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.1.233"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990719)82:2<213::AID-IJC11>3.0.CO;2-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196109\/10)14:5<901::AID-CNCR2820140502>3.0.CO;2-Q"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-8-200010170-00007"}],"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381716","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T13:57:04Z","timestamp":1745416624000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000381716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":18,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2015,9,1]]},"published-print":{"date-parts":[[2015,9,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000381716","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}