{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:28:36Z","timestamp":1789738116033,"version":"4.0.1"},"reference-count":33,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; BRAF mutation frequencies in melanoma subtypes have clinical implications and offer pathogenetic clues. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To characterize BRAF mutation status in melanoma of unknown primary (MUP) patients, in histological melanoma subtypes and by localization of primary tumors. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; In 179 patients with stage IV metastatic melanoma, BRAF mutation status, histological subtype and localization of primary (except for 29 MUP patients) were analyzed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; BRAF mutations were found in 44.3%, of which 80.5% were BRAF V600E and 19.5% showed non-V600E BRAF mutations. BRAF mutation frequency depended on histological subtype (57.4% superficial spreading melanoma, 54.7% nodular melanoma, 11.1% mucosal melanoma, 28.6% acral lentiginous melanoma) and concerning non-V600E BRAF mutations on localization of primary. In MUP the BRAF mutation pattern resembled superficial spreading and nodular melanomas. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; BRAF mutation frequencies depend on histological subtype and localization of primary melanoma. Non-V600E BRAF mutations mostly occur in patients with primaries on \u2018head and neck' as well as \u2018trunk' but not on \u2018extremities'.<\/jats:p>","DOI":"10.1159\/000381849","type":"journal-article","created":{"date-parts":[[2015,6,27]],"date-time":"2015-06-27T08:34:30Z","timestamp":1435394070000},"page":"127-133","source":"Crossref","is-referenced-by-count":12,"title":["Pathogenetic Implications of BRAF Mutation Distribution in Stage IV Melanoma Patients"],"prefix":"10.1159","volume":"231","author":[{"given":"Mirjam","family":"Baiter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerold","family":"Schuler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regine","family":"Schneider-Stock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Heinzerling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,6,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60868-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112302"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0631"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0052"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203421"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1210093"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406037"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408868"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.11.004"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12229"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg123"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050092"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10185.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00880.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nature00766"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.024"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(03)00150-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20481"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/nature13298"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820315)49:6<1106::AID-CNCR2820490607>3.0.CO;2-0"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930230104"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970701)80:1<60::AID-CNCR8>3.0.CO;2-J"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196511)18:11<1399::AID-CNCR2820181104>3.0.CO;2-R"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198702000-00008"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12153"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.622"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2011.07.029"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.143"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2012.10.002"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.07.013"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29335"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0686"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381849","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:58:30Z","timestamp":1745431110000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000381849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000381849","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}