{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:41:20Z","timestamp":1781134880192,"version":"3.54.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Careful clinical staging in patients with malignant pleural mesothelioma (MPM) is fundamental in management planning. Positron emission tomography\/computed tomography (PET\/CT) is increasingly recognized as an important staging modality. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; The purpose of this study was to assess whether the metabolic activity of the pleural tumor detected with PET\/CT correlates with specific endoscopic features and pleural distribution of the lesions as assessed by medical thoracoscopy. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Consecutive patients with MPM and available PET\/CT performed before thoracoscopy were separated into 2 groups, according to their standardized uptake value (SUV). Kaplan-Meier-analysis for survival was performed on groups with low and high SUV. Agreement between PET\/CT and thoracoscopy evaluation was analyzed using Cohen's kappa coefficient. The Wilcoxon test was used to compare the median SUV, and the &amp;#x03C7;&lt;sup&gt;2&lt;\/sup&gt; test was used to evaluate differences in endoscopic findings. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A total of 32 patients were included. The median maximum SUV (SUV max) was 6.1 and patients were separated into 2 groups based on this cutoff. Patients with SUV max &lt;6.1 had a better survival than those with SUV max \u22656.1 (p = 0.005). The comparison between PET\/CT and thoracoscopy showed a fair agreement for visceral and diaphragmatic pleural involvement and moderate agreement for the presence of nodular lesions. There was a statistically significant association between median SUV max and visceral pleural involvement; nodular lesions and visceral pleural involvement were more common in the high-SUV group than in the low-SUV group (p = 0.0012 and p = 0.03, respectively). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; PET\/CT data may be predictive of thoracoscopic features of MPM associated with prognosis and staging, but the correlation is moderate at best. A degree of disagreement exists between these two modalities, which supports thoracoscopy as the gold standard for assessment of local invasion in MPM.<\/jats:p>","DOI":"10.1159\/000381922","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T21:04:11Z","timestamp":1431378251000},"page":"558-564","source":"Crossref","is-referenced-by-count":15,"title":["Positron Emission Tomography\/Computed Tomography for the Pleural Staging of Malignant Pleural Mesothelioma: How Accurate Is It?"],"prefix":"10.1159","volume":"89","author":[{"given":"Valentina","family":"Pinelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Roca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Lucchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Laroumagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson","family":"Loundou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Dutau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Astoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-199907000-00015"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050152"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.1.8542156"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930715)72:2<394::AID-CNCR2820720214>3.0.CO;2-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00063109"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2003.07.005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(03)00292-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181c0a7ff"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00013706"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(03)00207-1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70342-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70469-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.116560"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2000.106529"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1089\/108497804323071913"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2005.03.007"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1148\/rg.346130089"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2012.10.017"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.03.068"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050276"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.8999"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/381922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:59:34Z","timestamp":1745431174000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000381922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":22,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000381922","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}