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We have previously shown that unlike other vertebrates that harbor both \u03b1 and \u03b2 GSK-3 genes, the \u03b1 gene is missing in birds. Therefore, birds can be used as a new animal model to study the roles of GSK-3\u03b2 in behavior and in regulating adult neurogenesis. In the present study, we inhibited GSK-3\u03b2 in brains of adult male zebra finches &lt;i&gt;(Taeniopygia guttata)&lt;\/i&gt; and accordingly investigated how this inhibition affects behavior and cell proliferation. Our results show that GSK-3 inhibition: (1) affects specific aspects of singing behavior, which might be related to social interactions in birds, and (2) differentially affects cell proliferation in various parts of the ventricular zone. Taken together, our study demonstrates a role of GSK-3\u03b2 in regulating singing behavior and neuronal proliferation in birds and highlights the importance of GSK-3\u03b2 in modulating cognitive abilities as well as social behavior.<\/jats:p>","DOI":"10.1159\/000382029","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T21:56:10Z","timestamp":1433541370000},"page":"233-244","source":"Crossref","is-referenced-by-count":9,"title":["GSK-3\u03b2 Inhibition Affects Singing Behavior and Neurogenesis in Adult 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