{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:49Z","timestamp":1787017909559,"version":"build-2736575974"},"reference-count":25,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Vasopressin plays an essential role in osmoregulation, but has deleterious effects in patients with ADPKD. Increased water intake to suppress vasopressin activity has been suggested as a potential renoprotective strategy. This study investigated whether urine and plasma osmolality can be used as reflection of vasopressin activity in ADPKD patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We measured urine and plasma osmolality, plasma copeptin concentration, total kidney volume (TKV, by MRI) and GFR (&lt;sup&gt;125&lt;\/sup&gt;I-iothalamate). In addition, change in estimated GFR (eGFR) during follow-up was assessed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Ninety-four patients with ADPKD were included (56 males, age 40 \u00b1 10, mGFR 77 \u00b1 32 ml\/min\/1.73 m&lt;sup&gt;2&lt;\/sup&gt;, TKV 1.55 (0.99-2.40) l. Urine osmolality, plasma osmolality and copeptin concentration were 420 \u00b1 195, 289 \u00b1 7 mOsmol\/l and 7.3 (3.2-14.6) pmol\/l, respectively. Plasma osmolality was associated with copeptin concentration (R = 0.54, p &lt; 0.001), whereas urine osmolality was not (p = 0.4). In addition, urine osmolality was not associated with TKV (p = 0.3), in contrast to plasma osmolality (R = 0.52, p &lt; 0.001) and copeptin concentration (R = 0.61, p &lt; 0.001). Fifty-five patients were followed for 2.8 \u00b1 0.8 years. Baseline plasma and urine osmolality were not associated with change in eGFR (p = 0.6 and p = 0.3, respectively), whereas baseline copeptin concentration did show an association with change in eGFR, in a crude analysis (St. \u03b2 = -0.41, p = 0.003) and also after adjustment for age, sex and TKV (St. \u03b2 = -0.23, p = 0.05). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; These data suggest that neither urine nor plasma osmolality are valid measures to identify ADPKD patients that may benefit from increasing water intake. Copeptin appears a better alternative for this purpose.<\/jats:p>","DOI":"10.1159\/000382081","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T17:01:29Z","timestamp":1430413289000},"page":"248-256","source":"Crossref","is-referenced-by-count":16,"title":["Urine and Plasma Osmolality in Patients with Autosomal Dominant Polycystic Kidney Disease: Reliable Indicators of Vasopressin Activity and Disease Prognosis?"],"prefix":"10.1159","volume":"41","author":[{"given":"Niek F.","family":"Casteleijn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Zittema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3356-6791","authenticated-orcid":false,"given":"Stephan J.L.","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy E.","family":"Boertien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo A.","family":"Gaillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin M.","family":"Spithoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Struck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron T.","family":"Gansevoort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,4,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107521"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nm935"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e3283621510"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205511"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006030251"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu093"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804458"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00790209"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04180609"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.23"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.38"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.285"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92026-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.060038"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2007.11.001"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0232"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1426"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200007000-00019"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04560510"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11311111"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118044"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.08.038"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs070"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2013.08.007"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/382081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/382081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:01:15Z","timestamp":1745416875000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000382081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,5,1]]},"published-print":{"date-parts":[[2015,5,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000382081","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725457250.793537896","asserted-by":"object"}]},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}