{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:37:55Z","timestamp":1789609075406,"version":"build-2803163510"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background:<\/i><\/b> Angiogenesis is the production of new blood vessels from an existing vascular network; it plays a critical role in solid tumor development and metastasis. <b><i>Objectives:<\/i><\/b> To assess angiogenesis in early cases of mycosis fungoides (MF) and to determine vascular patterns in MF dermoscopically. <b><i>Methods:<\/i><\/b> 25 patients with MF and 20 healthy controls were included. The MF lesions were assessed dermoscopically. CD34 immunohistochemistry was performed to count dermal microvessel density (MVD). <b><i>Results:<\/i><\/b> The total dermal MVD was significantly higher in MF patients (19.77 \u00b1 5.81) than in controls (4.44 \u00b1 3.16; p = 0.013). Among them, there were 10.8 \u00b1 4.1 sprouts of endothelial buds (clusters of cells per field) in patients and 2.4 \u00b1 2 in controls (p = 0.000). The dotted pattern of blood vessels was the most frequently encountered pattern in the MF lesions by dermoscopy. <b><i>Conclusions:<\/i><\/b> Our findings support that neoangiogenesis is significantly increased in early MF lesions and that the main dermoscopic feature of MF is dotted blood vessels.<\/jats:p>","DOI":"10.1159\/000382124","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T12:20:11Z","timestamp":1434543611000},"page":"82-86","source":"Crossref","is-referenced-by-count":21,"title":["Evaluation of Angiogenesis in Early Mycosis Fungoides Patients: Dermoscopic and Immunohistochemical Study"],"prefix":"10.1159","volume":"231","author":[{"given":"Manal","family":"Bosseila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadiga","family":"Sayed Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safinaz Salah","family":"El-Din Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha Ali","family":"Abd El Monaem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524033479465"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2013.1444"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70212"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2000.02104.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08852.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/BF02893406"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.281"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10868.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07426.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-055749"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2002.0630"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109\/10428199509054750"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn666"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00495.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/nm0195-27"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04499.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/01.EWX.0000440870.35969.e4"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/382124","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/382124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:01:31Z","timestamp":1745431291000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000382124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,6,1]]},"published-print":{"date-parts":[[2015,6,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000382124","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5128009","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}