{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:45:06Z","timestamp":1790671506150,"version":"4.1.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background:<\/i><\/b> Blue light irradiation reduces the proliferation of keratinocytes and modulates T-cell immune response in vitro and has been shown to reduce the severity of psoriasis vulgaris (Pv) in two clinical trials. <b><i>Objective:<\/i><\/b> Evaluation of safety and efficacy of long-term UV-free blue light treatment at home for mild Pv. <b><i>Methods:<\/i><\/b> Forty-seven patients with mild Pv were randomized for receiving high-intensity blue light treatment (HI: 453 nm LED, 200 mW\/cm<sup>2<\/sup>, n = 24) and low-intensity treatment (LI: 453 nm LED, 100 mW\/cm<sup>2<\/sup>, n = 23) of one Pv plaque for 12 weeks. A contralateral control plaque remained untreated. <b><i>Results:<\/i><\/b> Patient compliance and satisfaction were high. The primary endpoint, change from baseline (CfB) of the Local Psoriasis Severity Index, revealed a significant improvement of the target compared to the control plaques (&#x0394;CfB for the HI group: -0.92 \u00b1 1.10, p = 0.0005; for the LI group: -0.74 \u00b1 1.18, p = 0.0064). <b><i>Conclusion:<\/i><\/b> UV-free blue light home treatment is safe and improves Pv plaques.<\/jats:p>","DOI":"10.1159\/000430495","type":"journal-article","created":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T14:21:49Z","timestamp":1433341309000},"page":"24-34","source":"Crossref","is-referenced-by-count":80,"title":["Prospective Randomized Long-Term Study on the Efficacy and Safety of UV-Free Blue Light for Treating Mild Psoriasis Vulgaris"],"prefix":"10.1159","volume":"231","author":[{"given":"Stephanie","family":"Pfaff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Liebmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Born","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans F.","family":"Merk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"von Felbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,6,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041320"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.12.054"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(02)00066-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000210987"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.194"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020566"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12193"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000333364"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2009.00474.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04039.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/14764170600735912"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-005-0055-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/10447310802205776"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000250839"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314768"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005028.pub3"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2014.02.001"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.445"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.12.1599"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0857"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2986"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/430495","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/430495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/430495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:06:47Z","timestamp":1745431607000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000430495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,6,1]]},"published-print":{"date-parts":[[2015,6,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000430495","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}