{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:34:51Z","timestamp":1761896091258,"version":"3.40.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Early reduction of BCR-ABL1 transcript levels has been associated with improved outcome in chronic myeloid leukemia (CML) treatment. We evaluated 54 chronic-phase CML patients treated with imatinib who switched therapy to dasatinib (n = 33) or nilotinib (n = 21). BCR-ABL1 transcript levels were measured in peripheral blood using real-time quantitative PCR (RQ-PCR) every 3 months from the start of second-line treatment. Patients with BCR-ABL transcript levels &gt;10% at 3 months and &gt;1% at 6 months had significantly inferior progression-free (PFS) and event-free survival (EFS) than patients with RQ-PCR &lt;10% at 3 months and &lt;1% at 6 months (66 vs. 100%, p = 0.01, and 33 vs. 73%, p = 0.02, respectively). Patients with RQ-PCR &lt;10% at 3 months and &gt;1% at 6 months also had inferior PFS and EFS than patients with RQ-PCR &lt;10% at 3 months and &lt;1% at 6 months (48 vs. 100%, p = 0.002, and 25 vs. 73%, p &lt; 0.0001, respectively). Two measurements of BCR-ABL levels were better than a single one to stratify chronic-phase CML patients as failure after second-line therapy.<\/jats:p>","DOI":"10.1159\/000430835","type":"journal-article","created":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T21:06:47Z","timestamp":1435957607000},"page":"248-254","source":"Crossref","is-referenced-by-count":7,"title":["BCR-ABL1 Transcript Levels at 3 and 6 Months Are Better for Identifying Chronic Myeloid Leukemia Patients with Poor Outcome in Response to Second-Line Second-Generation Tyrosine Kinase Inhibitors after Imatinib Failure: A Report from a Single Institution"],"prefix":"10.1159","volume":"134","author":[{"given":"Beatriz Felicio","family":"Ribeiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Rocha","family":"Verg\u00edlio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana Cristina Martins","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Helena","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia Torresan","family":"Delamain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosana Antunes","family":"da Silveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmino Antonio","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dulcin\u00e9ia Martins","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey","family":"Dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vagner Oliveira","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gislaine Borba","family":"Oliveira-Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Lorand-Metze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia Borgia Barbosa","family":"Pagnano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,7,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441401"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062867"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.181"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.84"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.85"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-578567"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-501569"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.974047"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-12-544015"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21756"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.0779"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-229864"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20110056"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-0092"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2896"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.6565"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-273979"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.5217"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-383000"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-532341"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-166694"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.21.8230"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-080838"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/430835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/430835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:07:58Z","timestamp":1745431678000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000430835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000430835","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2015]]}}}