{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:33:19Z","timestamp":1745469199942,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; This study aimed to determine the efficacy of the risk of ovarian malignancy algorithm (ROMA), calculated using the carbohydrate antigen 125 (CA125) and human epididymis protein 4 (HE4) levels and the menopausal status, as a predictor of peritoneal dissemination in ovarian cancer. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The CA125 and HE4 levels and the ROMA were compared between ovarian cancer patients (n = 122) with or without peritoneal dissemination. The sensitivity, specificity, positive predictive value, and negative predictive value were calculated, and the results were compared with those of computed tomography (CT). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The CA125, HE4, and ROMA values differed significantly depending on the presence of peritoneal dissemination (p &lt; 0.0001). The cut-off values were 181 U\/ml for CA125, 161 pmol\/ml for HE4, 44% for the ROMA (premenopausal), and 86% for the ROMA (postmenopausal). Among these markers, the ROMA (premenopausal) was the strongest predictor of peritoneal dissemination, with a specificity of 85.0% and a positive predictive value of 81.3%. In addition, the detection rates of small disseminations with less than 2 cm in diameter for the ROMA (93%) and HE4 (60%) were superior to that of CT (53%). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The ROMA was a significant predictor of peritoneal dissemination and may be superior to CT for the detection of patients with small disseminations.<\/jats:p>","DOI":"10.1159\/000430858","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T12:18:07Z","timestamp":1434543487000},"page":"276-281","source":"Crossref","is-referenced-by-count":4,"title":["The Risk of Ovarian Malignancy Algorithm (ROMA) as a Predictive Marker of Peritoneal Dissemination in Epithelial Ovarian Cancer Patients"],"prefix":"10.1159","volume":"38","author":[{"given":"Yuji","family":"Ikeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosei","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kurosaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Miyara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Hanaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Shintani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadaaki","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsutoshi","family":"Oda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,5,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21166"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.02.026"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2010.09.008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2013.820705"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2232011081"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21288"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31819cda77"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.08.031"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.03.043"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-258"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.07.106"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.11.026"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e318248045b"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90803-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-149"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.05.017"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-010-0049-1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2011.075"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-013-3081-8"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/430858","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/430858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:08:07Z","timestamp":1745431687000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000430858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000430858","archive":["Portico"],"relation":{},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"type":"print","value":"2296-5270"},{"type":"electronic","value":"2296-5262"}],"subject":[],"published":{"date-parts":[[2015]]}}}