{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:33:21Z","timestamp":1745469201277,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>This study investigated the effect of a \u03b2-&amp;#x200B;hydroxyphosphonate analog of &lt;smlcap&gt;L&lt;\/smlcap&gt;-carnitine (L-CA) (CAS number: 1220955-&amp;#x200B;20-3, Component: 1221068-91-2, C&lt;sub&gt;12&lt;\/sub&gt;H&lt;sub&gt;29&lt;\/sub&gt;NO&lt;sub&gt;4&lt;\/sub&gt;PI), (3-Hexanaminium, 1-(dimethoxyphosphinyl)-2-hydroxy-N,N,N,5-&amp;#x200B;tetramethy-iodide (1:1), (2R, 3S)) on parameters related with type-2 diabetes in an in vitro model. Nontoxic concentrations of L-CA were assayed and compared to commercial &lt;smlcap&gt;L&lt;\/smlcap&gt;-carnitine effects. L-CA did not affect adipogenesis in normal cells, but an increment of TG accumulation was observed on insulin-resistant adipocytes (80%) when compared with resistant control. L-CA also stimulated glucose analog 2-NBDG uptakes on insulin-resistant adipocytes in a similar way as insulin when compared to insulin-resistant cells. Our results show that the L-CA promoted insulin-like responses on insulin-resistant adipocytes without appreciable pro-adipogenic effect in sensitive adipocytes.<\/jats:p>","DOI":"10.1159\/000430919","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T21:01:31Z","timestamp":1436216491000},"page":"99-106","source":"Crossref","is-referenced-by-count":3,"title":["Effect of a \u03b2-Hydroxyphosphonate Analogue of &lt;smlcap&gt;L&lt;\/smlcap&gt;-Carnitine on Insulin-Sensitive and Insulin-Resistant 3T3-L1 Adipocytes"],"prefix":"10.1159","volume":"96","author":[{"given":"Anaguiven","family":"Avalos-Soriano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"De la Cruz-Cordero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Josue","family":"L\u00f3pez-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge L.","family":"Rosado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel \u00c1ngel","family":"Duarte-V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Garcia-Gasca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,7,7]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/430919","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/430919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:08:53Z","timestamp":1745431733000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000430919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2015,9,1]]},"published-print":{"date-parts":[[2015,9,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000430919","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"type":"print","value":"0031-7012"},{"type":"electronic","value":"1423-0313"}],"subject":[],"published":{"date-parts":[[2015]]}}}