{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:49Z","timestamp":1787017909354,"version":"build-2736575974"},"reference-count":25,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Objective:<\/i><\/b> To compare specific characteristics and clinical outcomes of monomicrobial necrotizing fasciitis caused by <i>Aeromonas<\/i><i>hydrophila<\/i> and <i>Klebsiella pneumoniae<\/i>. <b><i>Material and Methods:<\/i><\/b> Cases of monomicrobial necrotizing fasciitis caused by <i>A. hydrophila<\/i> (n = 11) and <i>K. pneumoniae<\/i> (n = 7) over an 8-year period were retrospectively reviewed. Differences in mortality, patient characteristics, clinical presentations, and laboratory data were compared between the <i>A. hydrophila <\/i>and the <i>K. pneumoniae<\/i> groups. <b><i>Results:<\/i><\/b> The clinical signs and symptoms at the time of presentation did not differ significantly (p > 0.05) between the two groups. The <i>A. hydrophila <\/i>group had a significantly shorter interval between contact and admission (1.55 \u00b1 0.52 vs. 5.14 \u00b1 2.12 days, p < 0.001) and significant lower total white blood cell counts (10,245 \u00b1 5,828 vs. 19,014 \u00b1 11,370 cells\/mm<sup>3<\/sup>, p < 0.045) than the <i>K. pneumoniae<\/i> group in the emergency room. Hepatic dysfunction was associated with mortality in patients with <i>A. hydrophila<\/i> infection, while diabetes mellitus was associated with mortality in patients with <i>K. pneumoniae<\/i> infection. Overall, 5 (45.5%) patients in the <i>A. hydrophila<\/i> group and 3 (42.8%) in the <i>K. pneumoniae <\/i>group died. <b><i>Conclusion:<\/i><\/b> The initial clinical course of <i>A. hydrophila<\/i> monomicrobial necrotizing fasciitis was characterized by more rapidly progressive disease than that of the <i>K. pneumoniae<\/i> infection. Patients with hepatic dysfunction and necrotizing fasciitis should be suspected of having <i>A. hydrophila<\/i> infection, and diabetic patients with necrotizing fasciitis should be suspected of having <i>K. pneumoniae<\/i> infection initially.<\/jats:p>","DOI":"10.1159\/000431094","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T06:20:16Z","timestamp":1434003616000},"page":"416-423","source":"Crossref","is-referenced-by-count":37,"title":["Monomicrobial Necrotizing Fasciitis Caused by <b><i>Aeromonas<\/i><\/b> <b><i>hydrophila<\/i><\/b> and <b><i>Klebsiella pneumoniae<\/i><\/b>"],"prefix":"10.1159","volume":"24","author":[{"given":"Yao-Hung","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hsun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien-Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Han","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Chin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mel S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,6,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2010.01.028"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2007.10.030"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2011.11.001"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2008.112"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2008.04.015"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2007.12.001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.F.00580"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-008-0504-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2012.08.019"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.5.1298"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2000.0654"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.8.1730"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1771-y"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/IPC.0b013e3181730804"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2006.007"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis565"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis571"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1086\/313791"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-011-0338-7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31816a9ed3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-21-4-311"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2006.04.002"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-008-7272-3"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01181.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.01679"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/431094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/431094","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/431094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:10:37Z","timestamp":1745417437000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000431094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000431094","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}