{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:17:59Z","timestamp":1759814279201,"version":"3.40.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background:<\/i><\/b> Differentiating lymphocytic scarring alopecias may be difficult clinically as well as histopathologically. <b><i>Objective:<\/i><\/b> To investigate plasmacytoid dendritic cell (PDC) presence and distribution patterns and their diagnostic value in differentiating scarring alopecias of lupus erythematosus (LE) from lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA). <b><i>Methods:<\/i><\/b> Seventeen LE-associated alopecia, 20 LPP and 10 FFA cases were immunohistochemically tested for PDC presence\/distribution and activity. <b><i>Results:<\/i><\/b> LE-associated alopecia showed increased PDC content (\u226510% PDCs in all cases and \u226550% in 94% of cases), PDC clusters (100% of cases), and deeper dermal and perieccrine distribution (100% of cases) with involvement of the dermoepidermal junction (DEJ, 94% of cases), while the majority of LPP and FFA had <10% PDC content that was mainly confined to the upper dermis surrounding the hair infundibulum with rare DEJ involvement and rare clustering. <b><i>Conclusions:<\/i><\/b> Specific PDC-related parameters may serve as a useful diagnostic adjunct in the differentiation between LE-associated alopecia versus LPP and FFA.<\/jats:p>","DOI":"10.1159\/000431174","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T21:01:17Z","timestamp":1434488477000},"page":"158-163","source":"Crossref","is-referenced-by-count":26,"title":["Evaluation of the Diagnostic Value of Plasmacytoid Dendritic Cells in Differentiating the Lymphocytic Cicatricial Alopecias"],"prefix":"10.1159","volume":"231","author":[{"given":"Rima","family":"Sleiman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mazen","family":"Kurban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ossama","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,6,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200606000-00051"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3181bb6bc2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-009-9278-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0411190"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-004-0180-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01587.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2009.06.013"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06999.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/path.1699"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1996.tb01051.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12416"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12932"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/path.4233"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01291.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.11.010"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12139"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.12.1823"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177\/43.1.7822763"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.256"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.830"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.02.007"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5405.1183"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.130.6.770"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/431174","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/431174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:11:14Z","timestamp":1745431874000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000431174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000431174","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2015]]}}}