{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:00:10Z","timestamp":1792206010669,"version":"4.4.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background:<\/i><\/b> Eosinophils infiltrate intestinal tissue during necrotizing enterocolitis (NEC) and adult bowel diseases. We theorized that epithelial damage causes eosinophilic activation and recruitment at NEC onset. <b><i>Objective:<\/i><\/b> We studied the relationship between persistent blood eosinophilia and medical or surgical complications during NEC. <b><i>Methods:<\/i><\/b> NEC cases and controls at MU Children's Hospital (2008-2013) underwent review. A Likert scale measured NEC severity. We utilized an SPSS database for statistical analyses. <b><i>Results:<\/i><\/b> Of 50 NEC cases, infants in group 1 (n = 15) had eosinophilia <2 days after onset and those in group 2 (n = 25) had NEC but no persistent eosinophilia. Group 3 (n = 46) consisted of controls, i.e. infants without NEC matched for birth weight and gestational age and group 4 (n = 4) of preterm infants with infection and \u22645 days of eosinophilia. Hematologic assessment defined persistent eosinophilia as \u22655% eosinophils for \u22655 days after NEC onset. Absolute eosinophil counts were 2 times higher in group 1 than in group 2 (p = 0.002). The mean duration of eosinophilia was 8 days in group 1 versus 1 day in group 2 (p < 0.001). A Likert score of NEC severity was 3-fold higher in group 1 than in group 2 (p < 0.001). Compared to group 2, group 1 infants were 8 times more likely to have hepatic fibrosis or intestinal strictures. <b><i>Conclusions:<\/i><\/b> Early persistent blood eosinophilia is not currently a predictor of complications after the onset of NEC. This biomarker identifies immature infants at a high risk for adverse outcomes during NEC convalescence.<\/jats:p>","DOI":"10.1159\/000431305","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T21:01:26Z","timestamp":1436216486000},"page":"137-142","source":"Crossref","is-referenced-by-count":12,"title":["Early Persistent Blood Eosinophilia in Necrotizing Enterocolitis Is a Predictor of Late Complications"],"prefix":"10.1159","volume":"108","author":[{"given":"Lila S.","family":"Wahidi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Sherman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy M.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Zaghouani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Sherman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,7,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2008.10.004"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1005408"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2012.12.011"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-5-18"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00082"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059441"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.09.015"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nature12526"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400413"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000357004"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb13251.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.07.018"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2014.48"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000184"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407250"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20010573"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211226"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb13146.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.5.752"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303461"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2011.163"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211603"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1300575"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/431305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/431305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:12:45Z","timestamp":1745431965000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000431305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000431305","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}