{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:50:20Z","timestamp":1761238220639,"version":"3.40.5"},"reference-count":10,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T00:00:00Z","timestamp":1438732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T00:00:00Z","timestamp":1438732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; To assess the efficacy and safety of topography-guided photorefractive keratectomy (PRK) for keratoconus and to estimate the subsequent risk of progression. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This is a retrospective follow-up study. Between 1998 and 2013, 28 eyes of 23 patients (age 17-60) with grade 1-3 keratoconus received topography-guided PRK. Corrected-distance visual acuity (CDVA), keratometry, pachymetry, and corneal topography were assessed before, after 3 months, and at a late follow-up of a median of 7 years after the procedure. Postoperative complications including subsequent keratoplasty were noted. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Of the 28 eyes, 5 (18%) had undergone corneal transplantation at a median of 7 years (range 3-10) after PRK. Four eyes were not available for follow-up. In the remaining 19 eyes, CDVA was improved in 16 eyes (84.3%), reduced in 2 eyes (10.5%), and unchanged in 1 eye (5.2%). Thus, average CDVA had improved from 0.49 logMAR before PRK to 0.27 logMAR at 3 months, and to 0.24 at the long-term follow-up. The mean spherical equivalent was reduced from -6.2 to -3.7 dpt after 3 months and to -2.1 dpt at the late follow-up. Similarly, the mean cylinder was reduced from -4.2 to -3.0 dpt after 3 months and at the late follow-up. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Topography-guided PRK in keratoconus may be effective for reducing myopia and astigmatism and may offer a temporary or permanent alternative to keratoplasty in contact lens-intolerant keratoconus. In the present study, we found a low risk of keratoconus progression after PRK.<\/jats:p>","DOI":"10.1159\/000431306","type":"journal-article","created":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T21:01:26Z","timestamp":1438722086000},"page":"260-268","source":"Crossref","is-referenced-by-count":14,"title":["Photorefractive Keratectomy in Keratoconus"],"prefix":"10.1159","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8159-4004","authenticated-orcid":false,"given":"Deepali Sandeep","family":"Tambe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Ivarsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Hjortdal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S50119"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20130117-01"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.06.008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2012.08.058"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0671"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1253"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S52281"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.06.032"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000224634.72309.43"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2010.02197.x"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/431306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/431306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/431306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:12:46Z","timestamp":1745431966000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000431306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,5]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000431306","archive":["Portico"],"relation":{},"ISSN":["1663-2699"],"issn-type":[{"type":"electronic","value":"1663-2699"}],"subject":[],"published":{"date-parts":[[2015,8,5]]}}}