{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:08:16Z","timestamp":1787875696625,"version":"build-2784847793"},"reference-count":19,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background:<\/i><\/b> In nodal anaplastic large cell lymphoma, strong expression of galectin-3 (Gal-3) has been found, but only very few cases of primary cutaneous lymphoma have so far been examined. <b><i>Objectives:<\/i><\/b> To investigate 11 primary cutaneous anaplastic large cell lymphomas (PCALCL), 47 lymphomatoid papuloses (LYP) and 14 cases of transformed mycosis fungoides with CD30 expression (MF-T) for Gal-3 expression. <b><i>Methods: <\/i><\/b>A Gal-3 score was applied using a photo-based morphometric evaluation program. Double staining for CD30 and Gal-3 was performed. Furthermore, we recorded the cellular and extracellular sublocalization of the signal. <b><i>Results:<\/i><\/b> The Gal-3 expression in CD30+ tumor cells was significantly lower in MF-T in contrast to CD30+ lymphoproliferative disorders (CD30 LPD; p < 0.001), but we found no differences between PCALCL and LYP (p = 0.42). In PCALCL Gal-3 was more often localized in the cytoplasm in contrast to LYP, in which an equal distribution in the cytoplasm and the nucleus was more common (p = 0.9). <b><i>Conclusions:<\/i><\/b> The lower Gal-3 expression in MF-T in comparison to CD30 LPD might be an additional criterion to differentiate both entities. The different sublocalization of the Gal-3 signal might reflect a different biological function and behavior.<\/jats:p>","DOI":"10.1159\/000431313","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T21:01:19Z","timestamp":1434747679000},"page":"164-170","source":"Crossref","is-referenced-by-count":10,"title":["Galectin-3 Expression in Primary Cutaneous CD30-Positive Lymphoproliferative Disorders and Transformed Mycosis Fungoides"],"prefix":"10.1159","volume":"231","author":[{"given":"Christina","family":"Mitteldorf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Robson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tronnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique C.","family":"Pfaltz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6552-8629","authenticated-orcid":false,"given":"Werner","family":"Kempf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,6,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-351346"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e318289b1db"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90498-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1023\/B:GLYC.0000014084.01324.15"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090353"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2152\/jmi.57.152"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3892\/or.19.3.743"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2010.10.007"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021353"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00794.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.12.933"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181648d6d"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(04)00084-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(90)90226-S"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328362370f"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.13.6737"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00798.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.07.005"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/431313","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/431313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:12:47Z","timestamp":1745431967000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000431313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000431313","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}