{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:41:42Z","timestamp":1790620902735,"version":"4.1.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Parathyroid hormone (PTH) is important in the assessment of calcium metabolism disorders. However, there are few data regarding PTH levels in childhood and adolescence. &lt;b&gt;&lt;i&gt;Aim:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to determine PTH levels in a large group of healthy children and adolescents. &lt;b&gt;&lt;i&gt;Patients and Methods:&lt;\/i&gt;&lt;\/b&gt; We retrospectively evaluated PTH levels in 1,580 healthy Caucasian children and adolescents (849 females, 731 males, aged 2.0-17.2 years) with 25-hydroxyvitamin D [25(OH)D] levels \u226530 ng\/ml. All subjects with genetic, endocrine, hepatic, renal, or other known diseases were excluded. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The serum intact PTH concentration (median and inter-quartile range) was 23.00 (15.00-31.60) pg\/ml. In our population, the mean 25(OH)D value was 34.27 \u00b1 4.12 ng\/ml. The median PTH concentration in boys was 23.00 (15.00-32.00) pg\/ml, whereas in girls it was 23.10 (15.00-31.10) pg\/ml. However, in girls, PTH levels significantly increased in the age group of 8.1-10.0 years compared to the age group of 2.1-4.0 years (p &lt; 0.0001), whereas in boys it significantly increased in the age groups of 10.1-12.0 years (p &lt; 0.0001) and 12.1-14.0 years (p &lt; 0.0001), leading to the hypothesis of a relationship between PTH level and pubertal and bone growth spurts. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; PTH levels in healthy children and adolescents covered a narrower range than the adult values. Obtaining reference values of PTH in childhood and adolescence could aid in the estimation of appropriate values of bone metabolites.<\/jats:p>","DOI":"10.1159\/000432399","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T21:06:42Z","timestamp":1435612002000},"page":"124-129","source":"Crossref","is-referenced-by-count":27,"title":["Parathyroid Hormone Levels in Healthy Children and Adolescents"],"prefix":"10.1159","volume":"84","author":[{"given":"Stefano","family":"Stagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Cavalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Mola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Marchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Seminara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Brandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"de Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(00)00336-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14302.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0167"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3109\/17453679508995567"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109\/07853899309147301"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.139"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/ar127"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114484"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.31"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.380"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70064-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050030"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/adc.51.3.170"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000281018"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/er.22.4.477"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.124966"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.9.1856"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.11.1208"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104825"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2014.19.2.86"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000354645"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3182"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.09.026"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneb.2008.05.001"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047264"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/432399","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/432399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:13:17Z","timestamp":1745431997000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000432399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000432399","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}