{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:01:59Z","timestamp":1787612519512,"version":"build-2736575974"},"reference-count":25,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; To examine the validity of Addenbrooke's Cognitive Examination III (ACE-III) in detecting early dementia in UK memory clinic patients aged 75-85 years. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The ACE-III was administered to 59 patients prior to diagnosis. The extent to which scores predicted the membership of the dementia or no-dementia group was explored using receiver operating characteristic curve analysis and other parameters of diagnostic performance. Thirty-three participants (55.9%) were diagnosed with dementia (Alzheimer's disease = 56.3%, Alzheimer's disease with cerebrovascular disease = 31.3%, and vascular dementia = 12.5%). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The optimal cut-off for detecting dementia was 81\/100 (scores &lt;81 indicating dementia with a sensitivity of 0.79, a specificity of 0.96, and a positive predictive value of 0.96), with superiority over published cut-offs (88\/100 and 82\/100) at medium and lower prevalence rates. The number of years of full-time education had a significant positive relationship to total ACE-III scores (r = 0.697, p &lt; 0.001) for the no-dementia group. Exploratory analysis indicated that optimal cut-offs were different for higher versus lower education groups. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The ACE-III has excellent accuracy for the detection of dementia in day-to-day clinical practice. Lower cut-offs than those specified in the index paper, and the consideration of the patients' years of full-time education may be necessary for optimal diagnostic performance.<\/jats:p>","DOI":"10.1159\/000433522","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T21:01:33Z","timestamp":1438030893000},"page":"222-232","source":"Crossref","is-referenced-by-count":29,"title":["An Investigation of the Utility of the Addenbrooke's Cognitive Examination III in the Early Detection of Dementia in Memory Clinic Patients Aged over 75 Years"],"prefix":"10.1159","volume":"40","author":[{"given":"Michael T.","family":"Jubb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000351671"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1610"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2771"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610213002329"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrleng.2014.05.001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000369883"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2639"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2769"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/gps.3884"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000345562"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-6612.2010.00446.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/WNN.0b013e3181c5e2e5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03173.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2010.00624.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610211001190"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000336909"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000328165"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000334657"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2331"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01388.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e6717"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010460"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/433522","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/433522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:14:57Z","timestamp":1745432097000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000433522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":25,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2015,9,1]]},"published-print":{"date-parts":[[2015,9,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000433522","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}