{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:19:30Z","timestamp":1768681170254,"version":"3.49.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,7,9]],"date-time":"2015-07-09T00:00:00Z","timestamp":1436400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,7,9]],"date-time":"2015-07-09T00:00:00Z","timestamp":1436400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background and Purpose:&lt;\/i&gt;&lt;\/b&gt; To report outcomes and toxicity after proton beam radiotherapy for non-peripapillary choroidal and ciliary body melanoma considered unsuitable for other eye-sparing therapies. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; An existing database of 77 patients with non-peripapillary tumors treated at TRIUMF, Canada, including patient, tumor, and treatment characteristics, was updated with ocular complications and follow-up status from chart reviews. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Most of the patients had large tumors: 61% were T3\/T4 tumors (AJCC classification), while 48% were large by the Collaborative Ocular Melanoma Study classification. The median thickness was 7.1 mm, and the ciliary body was involved in 35%. After 5 and 10 years, the actuarial ocular tumor control rate was 85 and 85%, metastasis-free survival was 72 and 57%, overall survival was 77 and 63%, the enucleation rate was 22 and 22%, and complete blindness was found in 38 and 38%, respectively. On univariate analysis, patients with ciliary body involvement had significantly worse metastasis-free survival and overall survival rates compared to patients without ciliary body involvement (p &lt; 0.001). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Proton therapy for large anteriorly located tumors resulted in acceptable ocular tumor control and survival rates. The risk of blindness and severe toxicity requiring enucleation was low, and a substantial proportion of patients maintained useful vision.<\/jats:p>","DOI":"10.1159\/000433546","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T21:01:26Z","timestamp":1436389286000},"page":"29-35","source":"Crossref","is-referenced-by-count":27,"title":["Outcomes of Proton Beam Radiotherapy for Large Non-Peripapillary Choroidal and Ciliary Body Melanoma at TRIUMF and the BC Cancer Agency"],"prefix":"10.1159","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7099-1204","authenticated-orcid":false,"given":"Britta","family":"Weber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Paton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Pickles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.01.032"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(93)31446-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.01.016"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjopt.2013.06.014"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.12.1665"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01277-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.06.038"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.01.058"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.195594"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000334401"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.10.017"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4103\/0974-620X.116652"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1118\/1.595258"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2307\/3579588"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.07.1688"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01560-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.01.020"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.77"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.118.8.1066"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1977.04450010065005"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1983.01040020896012"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15571"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000051"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/433546","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/433546","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/433546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:15:23Z","timestamp":1745432123000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000433546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,9]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000433546","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"value":"2296-4681","type":"print"},{"value":"2296-4657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,9]]}}}