{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:44:31Z","timestamp":1785242671715,"version":"3.55.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background\/Aims:<\/i><\/b> This study aimed at comparing the efficacy and tolerability of 5 different regimens for <i>Helicobacter pylori<\/i> eradication in recent years. <b><i>Methods:<\/i><\/b><i>H. pylori<\/i>-positive patients with dyspeptic symptoms were included and separated into 5 groups. The \u2018PAC group' was given pantoprazole, amoxicillin and clarithromycin for 14 days. The \u2018PAM group' was given pantoprazole, amoxicillin and metronidazole for 14 days. The \u2018bismuth-containing group' was given pantoprazole, bismuth subsalicylate, tetracycline and metronidazole for 14 days. The \u2018sequential group' was given pantoprazole and amoxicillin for 5 days, followed by pantoprazole, tetracycline, and metronidazole for the next 5 days. The \u2018concomitant group' was given pantoprazole, amoxicillin, tetracycline, and metronidazole for 10 days. Eradication was assessed through the urea breath test on 6 weeks after eradication therapy. <b><i>Results:<\/i><\/b> The eradication rate of intention-to-treat\/per protocol were 42\/48.3% in the PAC group, 52\/54.2% in the PAM group, 62\/77.5% in the bismuth group, 71\/80.7% in the sequential group and 72\/83.7% in concomitant group. The frequency of mild and moderate side effects was similar between groups. <b><i>Conclusion:<\/i><\/b> The concomitant and sequential therapies are an effective treatment for <i>H. pylori<\/i>. Bismuth-containing therapy is superior to conventional triple therapies; however, the eradication rate is not satisfactory. In our country, conventional triple therapies are not effective for eradication.<\/jats:p>","DOI":"10.1159\/000434627","type":"journal-article","created":{"date-parts":[[2015,7,10]],"date-time":"2015-07-10T21:01:30Z","timestamp":1436562090000},"page":"55-59","source":"Crossref","is-referenced-by-count":19,"title":["Current Status of Five Different Regimens for Empiric First-Line <b><i>Helicobacter pylori<\/i><\/b> Eradication in Turkey"],"prefix":"10.1159","volume":"92","author":[{"given":"Gokhan","family":"Gungor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Bagl\u0131cakoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ertugrul","family":"Kayacetin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Biyik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramazan","family":"Ucar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Goktepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Ataseven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,7,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.12.1672"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00563.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613015"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.53.1.34"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2006.11.011"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01461.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2004.01818.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00671.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.101634"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302084"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31802e7ee7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.02.011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31819c7320"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01759.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2007.00308.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2008.03.009"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.09.030"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31826015b0"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/434627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/434627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:16:09Z","timestamp":1745432169000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000434627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,9,1]]},"published-print":{"date-parts":[[2015,9,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000434627","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}