{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T04:39:28Z","timestamp":1766983168911,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background and Aims:&lt;\/i&gt;&lt;\/b&gt; Isolated premature menarche is isolated or recurrent vaginal bleeding in a female in the absence of appropriate secondary sexual characters. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Retrospective chart review of patients with premature menarche, followed by a telephone questionnaire. Charts of patients evaluated in the Pediatric Endocrine Clinic for premature vaginal bleeding from 1982-2013 were reviewed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Of 21 patients identified, 17 could be contacted. Five newly diagnosed patients were recruited during the course of the study. The median age at initial presentation was 7 years. Most patients presented with Tanner I sexual development. Some had more advanced breast staging, which regressed later. All had prepubertal baseline and stimulated gonadotropins. Most of the patients reported a single or few episodes of menses. Two reported continuation of irregular bleeding into adulthood. All reported an adult height within the midparental target height. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Premature menarche in the absence of other appropriate secondary sexual characteristics is a benign entity. Most patients have a few isolated episodes of menses that stop spontaneously; some may continue to have periods into adulthood. Unlike true puberty, these patients do not demonstrate advanced skeletal maturation, and the adult height is normal. Fertility appears to be normal.<\/jats:p>","DOI":"10.1159\/000435882","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T21:01:33Z","timestamp":1436302893000},"page":"217-222","source":"Crossref","is-referenced-by-count":7,"title":["Outcome of Isolated Premature Menarche: A Retrospective and Follow-Up Study"],"prefix":"10.1159","volume":"84","author":[{"given":"Sehar","family":"Ejaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Lane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,7,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(54)91363-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.58.2.142"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81074-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.79.2.8045957"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01488.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.881794"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1216"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2307\/1126417"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1995.tb13691.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000181436"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80501-1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031532"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2013-0415"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/adc.54.6.472"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.09.005"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/435882","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/435882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:34:49Z","timestamp":1745429689000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000435882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000435882","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5128360","asserted-by":"subject"}]},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2015]]}}}