{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:02:14Z","timestamp":1772798534244,"version":"3.50.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2015,7,9]],"date-time":"2015-07-09T00:00:00Z","timestamp":1436400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2015,7,9]],"date-time":"2015-07-09T00:00:00Z","timestamp":1436400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Gastroenterol"],"abstract":"<jats:p>Glycogenic hepatopathy (GH) remains underrecognized in adults as most clinicians mistake it for the more common hepatic abnormality associated with uncontrolled diabetes mellitus in this age group, non-alcoholic fatty liver disease. This is also complicated by the fact that both entities are indistinguishable on liver ultrasound. We herein describe a similar predicament in which a young adult female presented with bilateral upper quadrant abdominal pain, tender hepatomegaly, lactic acidosis and a &gt;10-fold increase in liver enzymes, which worsened after the administration of high-dose steroids. Despite intravenous normal saline resuscitation, serum transaminitis persisted in a fluctuating manner. Ultimately, a liver biopsy confirmed GH. Biochemically, GH is driven by high amounts of both circulating glucose and insulin or by the administration of high-dose steroids. Improving glycemic control is the mainstay of treatment for GH. However, in our case, improvement in glycated hemoglobin of just 0.6% was enough to achieve symptomatic relief, supporting recent claims of the involvement of other identified factors in disease development.<\/jats:p>","DOI":"10.1159\/000437048","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T21:01:27Z","timestamp":1436389287000},"page":"221-226","source":"Crossref","is-referenced-by-count":28,"title":["Glycogenic Hepatopathy: Thinking Outside the Box"],"prefix":"10.1159","volume":"9","author":[{"given":"Nishant","family":"Parmar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muslim","family":"Atiq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Austin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross A.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Smyrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kabir","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2007.02085.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00132-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200604000-00012"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v4.i3.51"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-2-227"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197010292831807"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.20047"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0270-9139(95)90305-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.134"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1148\/rg.314105215"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPDOMY5RI5TPMN"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2013.19.4.421"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23402"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajg.2013.08.001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i42.5286"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12016"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198601000-00008"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199611000-00003"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2000.00547.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000239510.27872.07"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2007.11.002"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2007.11.004"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06178.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ12-0081"}],"container-title":["Case Reports in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/437048","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/437048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/437048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:36:42Z","timestamp":1745429802000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000437048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,9]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000437048","archive":["Portico"],"relation":{},"ISSN":["1662-0631"],"issn-type":[{"value":"1662-0631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,9]]}}}