{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:08:00Z","timestamp":1792598880115,"version":"4.5.0"},"reference-count":10,"publisher":"Bioscientifica","issue":"4","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":3839,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Hypertrophic osteoarthropathy (HOA) is a rare condition characterized by bone and joint pain and digital clubbing usually associated with bronchopulmonary diseases. Primary HOA is rare and the pathogenesis remains unclear. Objectives: Cases of HOA as a paraneoplastic syndrome associated with thyroid carcinoma are very rare - only 2 cases have been described in the literature. Results: We present the first case of a 40-year-old patient affected by HOA associated with invasive differentiated follicular thyroid carcinoma operated in 2 stages. Both operations were followed by radioiodine ablation, and then a rapid unresectable local recurrence developed requiring cervical radiotherapy (70 Gy). A second treatment with 100 mCi of &amp;lt;sup&amp;gt;131&amp;lt;\/sup&amp;gt;I confirmed it was a refractory thyroid cancer. Further surgery confirmed a poorly differentiated follicular cancer and 12 cycles of chemotherapy by gemcitabine and oxaliplatin followed. During the 8 years of follow-up, cervical recurrence was stable, but severe episodes of hemoptysis occurred requiring iterative embolization of the bronchial and tracheal arteries. Other lung diseases were excluded. Digital clubbing appeared, which was associated with arthritis, bone pain and inflammatory syndrome. X-rays and magnetic resonance imaging found periosteal apposition in the long bones; bone scintigraphy confirmed the HOA diagnosis. Other causes of arthritis were eliminated. She was treated with colchicine, corticosteroids and nonsteroidal anti-inflammatory drugs, but only the combination of methotrexate and hydroxychloroquine reduced the morphine requirements. Conclusion: HOA is exceptionally associated with thyroid cancer and we raised the hypothesis of the secretion of a circulating factor in a patient with invasive and recurrent follicular thyroid cancer, refractory to radioiodine.<\/jats:p>","DOI":"10.1159\/000437052","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T17:02:53Z","timestamp":1439485373000},"page":"266-270","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":11,"title":["Hypertrophic Osteoarthropathy and Follicular Thyroid Cancer: A Rare Paraneoplastic Syndrome"],"prefix":"10.1530","volume":"4","author":[{"given":"Martina","family":"Tavarelli","sequence":"first","affiliation":[{"name":"1Unit\u00e9 Thyro\u00efde Tumeurs Endocrines, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Sarfati","sequence":"additional","affiliation":[{"name":"1Unit\u00e9 Thyro\u00efde Tumeurs Endocrines, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"De Gennes","sequence":"additional","affiliation":[{"name":"2Service de M\u00e9decine Interne Immuno-clinique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Haroche","sequence":"additional","affiliation":[{"name":"3Service de M\u00e9decine Interne 2, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Buffet","sequence":"additional","affiliation":[{"name":"1Unit\u00e9 Thyro\u00efde Tumeurs Endocrines, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Ghander","sequence":"additional","affiliation":[{"name":"1Unit\u00e9 Thyro\u00efde Tumeurs Endocrines, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Marc","family":"Simon","sequence":"additional","affiliation":[{"name":"4Service de Radioth\u00e9rapie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"M\u00e9n\u00e9gaux","sequence":"additional","affiliation":[{"name":"5Service de Chirurgie G\u00e9n\u00e9rale et Digestive, Groupe Hospitalier et Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re, Institut du Cancer, Universit\u00e9 Pierre et Marie Curie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Leenhardt","sequence":"additional","affiliation":[{"name":"1Unit\u00e9 Thyro\u00efde Tumeurs Endocrines, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2015,8,14]]},"reference":[{"key":"2026070712464456000_ref1","doi-asserted-by":"crossref","unstructured":"Uppal S, Diggle CP, Carr IM, Fishwick CW, Ahmed M, Ibrahim GH, Helliwell PS, Latos-Bielenska A, Phillips SE, Markham AF, Bennett CP, Bonthron DT: Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy. Nat Genet 2008;40:789-793.10.1038\/ng.15318500342","DOI":"10.1038\/ng.153"},{"key":"2026070712464456000_ref2","doi-asserted-by":"crossref","unstructured":"Zhang Z, He JW, Fu WZ, Zhang CQ, Zhang ZL: Mutations in the SLCO2A1 gene and primary hypertrophic osteoarthropathy: a clinical and biochemical characterization. J Clin Endocrinol Metab 2013;98:923-933.10.1210\/jc.2012-356823509104","DOI":"10.1210\/jc.2012-3568"},{"key":"2026070712464456000_ref3","doi-asserted-by":"crossref","unstructured":"Izumi M, Takayama K, Yabuuchi H, Abe K, Nakanishi Y: Incidence of hypertrophic pulmonary osteoarthropathy associated with primary lung cancer. Respirology 2010;15:809-812.10.1111\/j.1440-1843.2010.01769.x20497387","DOI":"10.1111\/j.1440-1843.2010.01769.x"},{"key":"2026070712464456000_ref4","unstructured":"Dexemple P, Leleu JP, Monnier A, Delamarre B, Beda BY: Ost\u00e9opathie hypertrophiante et cancer thyroidien. Rev Rhum Mal Osteoartic 1984;51:105-107.6710059"},{"key":"2026070712464456000_ref5","unstructured":"Vico P, Delcorde A, Rahier I, Treille De Grandsaigne S, Famaey JP, Body JJ: Hypertrophic osteoartropathy and thyroid cancer. J Rheumatol 1992;19:1153-1156.1512778"},{"key":"2026070712464456000_ref6","doi-asserted-by":"crossref","unstructured":"Manuel ML: Exploring the cause of the most ancient clinical sign of medicine: finger clubbing. Semin Arthritis Rheum 2007;36:380-385.10.1016\/j.semarthrit.2006.11.00417276498","DOI":"10.1016\/j.semarthrit.2006.11.004"},{"key":"2026070712464456000_ref7","doi-asserted-by":"crossref","unstructured":"Dickinson CJ, Martin JF: Megakaryocytes and platelet clumps as the cause of finger clubbing. Lancet 1987;2:1434-1435.10.1016\/S0140-6736(87)91132-92891996","DOI":"10.1016\/S0140-6736(87)91132-9"},{"key":"2026070712464456000_ref8","unstructured":"Martinez-Lavin M: Pathogenesis of hypertrophic osteoarthropathy. Clin Exp Rheumatol 1992;10(suppl 7):49-50.1623674"},{"key":"2026070712464456000_ref9","doi-asserted-by":"crossref","unstructured":"Atkinson S, Fox SB: Vascular endothelial growth factor (VEGF)-A and platelet-derived growth factor (PDGF) play a central role in the pathogenesis of digital clubbing. J Pathol 2004;203:721-728.10.1002\/path.156515141388","DOI":"10.1002\/path.1565"},{"key":"2026070712464456000_ref10","doi-asserted-by":"crossref","unstructured":"Peloso LC, Gerber DE: Paraneoplastic syndromes: an approach to diagnosis and treatment. Mayo Clin Proc 2010;85:838-854.10.4065\/mcp.2010.009920810794","DOI":"10.4065\/mcp.2010.0099"}],"container-title":["European Thyroid Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/437052","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article-pdf\/4\/4\/266\/29534\/etj437052.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article-pdf\/4\/4\/266\/29534\/etj437052.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:07:07Z","timestamp":1783444027000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article\/4\/4\/266\/3990\/Hypertrophic-Osteoarthropathy-and-Follicular"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,14]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000437052","relation":{},"ISSN":["2235-0802","2235-0640"],"issn-type":[{"value":"2235-0802","type":"electronic"},{"value":"2235-0640","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8,14]]}}}