{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:36:07Z","timestamp":1760985367150,"version":"3.40.5"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Bilateral truncal ligation (BTL) of the inferior thyroid artery (ITA) is frequently used during subtotal thyroidectomy to reduce the risk of post-operative bleeding as well as to reduce the blood loss intra-operatively. However, its effect on parathyroid function has not been evaluated in relation to age, residual and resected thyroid volume. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A total of 83 patients were randomized to receive non-BTL or BTL. After bilateral resection, the residual thyroid tissue on each side was measured by intra-operative ultrasonography. Laboratory and clinical examinations were performed the day before operation, intra-operatively and on post-operative days 2 and 5. The primary outcome measure was the difference in intact parathormone (PTHi) on post-operative day 5. Secondary outcomes were laboratory-diagnosed hypocalcaemia or hypoparathyroidism and clinically manifest hypoparathyroidism, respectively. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; PTHi on post-operative day 5 was significantly lower in the BTL group (29.4 vs. 34.7 ng\/l in the non-BTL group, p = 0.033), especially in 61- to 80-year-old patients (0 vs. -7.91 ng\/l, p = 0.029). The biggest decline in PTHi was found in the BTL group (-14.067 ng\/l PTH, p = 0.018) with a residual thyroid volume of 0.5-1.9 ml. There were two cases of asymptomatic hypoparathyroidism in each group (5.1 vs. 4.8%, respectively, p = 1.000). The only case of clinically manifest hypoparathyroidism was in a BTL group patient aged 64 years (2.4%, p = 1.000). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; BTL of the ITA during subtotal thyroidectomy causes a larger decrease in PTH but does not lead to a significantly higher rate of clinically manifest hypoparathyroidism. BTL of the ITA, age &gt;61 years, and a very small thyroid remnant (&lt;2 ml) may be risk factors for post-operative hypoparathyroidism.<\/jats:p>","DOI":"10.1159\/000437094","type":"journal-article","created":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T21:01:22Z","timestamp":1438808482000},"page":"141-150","source":"Crossref","is-referenced-by-count":6,"title":["Bilateral Truncal Ligation of the Inferior Thyroid Artery during Bilateral Subtotal Thyroidectomy Causes a Decrease in Parathormone without Clinically Manifest Hypoparathyroidism: A Randomized Clinical Trial"],"prefix":"10.1159","volume":"55","author":[{"given":"Astrid","family":"Kebsch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Utz","family":"Settmacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7543-0193","authenticated-orcid":false,"given":"Thomas","family":"Lesser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,8,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2003.61"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215106003501"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0803050"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(02)01310-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-003-6903-1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-69912012000600006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800700706"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010221"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviscsurg.2010.08.020"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/110241500750009096"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3109\/02841867809127937"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1070506"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-190710000-00001"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/BF01799024"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1988.01860140066023"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1590\/S0041-87812000000400002"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800811215"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-011-0774-y"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.52.199"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-010-0491-7"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-69912012000600006"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.483"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/437094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/437094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:37:03Z","timestamp":1745429823000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000437094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000437094","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"type":"print","value":"0014-312X"},{"type":"electronic","value":"1421-9921"}],"subject":[],"published":{"date-parts":[[2015]]}}}