{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:43:11Z","timestamp":1774604591581,"version":"3.50.1"},"reference-count":11,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background:<\/i><\/b> High-frequency oscillatory ventilation (HFOV) with volume guarantee (VG) is a new ventilation mode that allows the clinician to set a mean tidal volume to be delivered. <b><i>Objective:<\/i><\/b> This study aimed to investigate whether HFOV with a VG option may result in constant tidal volume delivery and less fluctuant CO<sub>2<\/sub> levels compared to HFOV alone in premature infants with respiratory distress syndrome (RDS). <b><i>Methods:<\/i><\/b> Inborn infants at less than 32 weeks of gestation with RDS requiring invasive mechanical ventilation were eligible. Patients were randomized to receive HFOV + VG or HFOV alone as the initial ventilator mode and then crossed over to the other mode. HFOV was performed with \u2018optimal lung volume strategy' during both of the periods. <b><i>Results:<\/i><\/b> Twenty infants were evaluated. The mean high-frequency tidal volume (VT<sub>hf<\/sub>) and CO<sub>2<\/sub> diffusion coefficient (DCO<sub>2<\/sub>) were significantly higher in the HFOV + VG mode than HFOV alone. HFOV + VG maintains VT<sub>hf<\/sub> within the target range more consistently than HFOV. The incidences of hypocarbia and hypercarbia were lower in HFOV with VG than HFOV alone. <b><i>Conclusion:<\/i><\/b> This is the first prospective, randomized, short-term crossover clinical study that compared HFOV with and without VG in infants with acute RDS. Because of the lower VT<sub>hf<\/sub> fluctuation and lower incidences of out-of-target PCO<sub>2<\/sub> levels, HFOV combined with VG seems to be feasible for preterm infants. However, the results should be interpreted with caution due to the small sample size and short-term crossover design of the study.<\/jats:p>","DOI":"10.1159\/000437204","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T21:01:23Z","timestamp":1441054883000},"page":"277-282","source":"Crossref","is-referenced-by-count":46,"title":["Impact of Volume Guarantee on High-Frequency Oscillatory Ventilation in Preterm Infants: A Randomized Crossover Clinical Trial"],"prefix":"10.1159","volume":"108","author":[{"given":"Burcin","family":"Iscan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuray","family":"Duman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Funda","family":"Tuzun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0004-1761","authenticated-orcid":false,"given":"Abdullah","family":"Kumral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4253-4222","authenticated-orcid":false,"given":"Hasan","family":"Ozkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,9,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.05.043"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2011.687"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000104.pub4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp020082"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01120.2011"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20367"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2601-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304613"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.02382"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/593915"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.39"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/437204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/437204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:37:43Z","timestamp":1745429863000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000437204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000437204","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}