{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:12:52Z","timestamp":1773681172889,"version":"3.50.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T00:00:00Z","timestamp":1437091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T00:00:00Z","timestamp":1437091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<b><i>Purpose:<\/i><\/b> Pathological vascular differentiation in retinal vein occlusion (RVO)-related neovessel formation remains poorly characterized. The role of intraocular lymphatic-like differentiation or endothelial progenitor cell activity has not been studied in this disease. <b><i>Methods:<\/i><\/b> Vitrectomy was performed in an eye with hemi-RVO; the neovessel membrane located at the optic nerve head was removed and subjected to immunohistochemistry. Characterization of the neovascular tissue was performed using hematoxylin and eosin, \u03b1-smooth muscle actin, and the pan-endothelial cell (EC) adhesion molecule CD31. The expression of lymphatic EC markers was studied by lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), podoplanin (PDPN), and prospero-related homeobox protein 1 (Prox-1). Potential vascular stem\/progenitor cells were identified by active cellular proliferation (Ki67) and expression of the stem cell marker CD117. <b><i>Results:<\/i><\/b> The specimen contained blood vessels lined by ECs and surrounded by pericytes. Immunoreactivity for LYVE-1 and Prox-1 was detected, with Prox-1 being more widely expressed in the active Ki67-positive lumen-lining cells. PDPN expression was instead found in the cells residing in the extravascular tissue. Expression of the stem cell markers CD117 and Ki67 suggested vascular endothelial progenitor cell activity. <b><i>Conclusions:<\/i><\/b> Intraocular lymphatic-like differentiation coupled with progenitor cell activation may be involved in the pathology of neovessel formation in ischemia-induced human hemi-RVO.<\/jats:p>","DOI":"10.1159\/000437254","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T21:02:53Z","timestamp":1437080573000},"page":"228-238","source":"Crossref","is-referenced-by-count":10,"title":["A Case of Abnormal Lymphatic-Like Differentiation and Endothelial Progenitor Cell Activation in Neovascularization Associated with Hemi-Retinal Vein Occlusion"],"prefix":"10.1159","volume":"6","author":[{"given":"Sirpa","family":"Loukovaara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Gucciardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauliina","family":"Repo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jouko","family":"Lohi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petri","family":"Salven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaisa","family":"Lehti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,7,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12223"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7040-z"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf470"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2545"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/783163"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75392"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.11.003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12741"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.144.4.789"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81511-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1413.001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001407"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04614.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10163"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13453"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nature07083"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/437254","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/437254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/437254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:38:39Z","timestamp":1745429919000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000437254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,17]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000437254","archive":["Portico"],"relation":{},"ISSN":["1663-2699"],"issn-type":[{"value":"1663-2699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,17]]}}}